Tag Archives: lipotoxicity

Insulin Resistance, Lipotoxicity, Type 2 Diabetes, and Atherosclerosis

This will bore most readers.

I just want to mention a scientific review article from 2009 that reviews insulin activity (down to a molecular level) in the context of type 2 diabetes, atherosclerosis, and insulin resistance.  Towards the end it starts sounding like an informercial for thiazolidinedione drugs

The author makes a great case for the dangers of hyperinsulinemia.

Good reference overall.

R. A. DeFronzo wrote “Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009.”   Diabetologia, 2010 (53); 1,270-1,287.  doi: 10.1007/s00125-010-1684-1

Steve Parker, M.D.

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Filed under Causes of Diabetes, coronary heart disease