How Do Ozempic, Zepbound, Wegovy, and Mounjaro Work?

This alleged pathologist explains how drugs like Ozempic, Zepbound, Wegovy, and Mounjaro work to reduce appetite and lead to weight loss. Which could help if you have type 2 diabetes. These drugs are analogs of either GLP-1 (glucose-like peptide-1) or GIP (glucose-dependent insulinotropic polypeptide), or a combination of both.

The doctor gets pretty technical. Click for a simpler explanation from UCHealth.

These drugs make me think of the 1970s TV add for Chiffon margarine telling us “It’s not nice to fool Mother Nature.”

—–Steve Parker, M.D.

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Should You Worry About Microplastics?

It’s getting harder for me to ignore microplastics. They contaminate our water, food, soil, oceans, and air. The guy in this video says the average adult brain contains as much invasive plastic as a typical plastic fork (5 grams?). These plastics are said to cause medical problems although I’m not sure of the strength of the evidence. Very few physicians know about this issue. The video speaker below talks about nanoplastics but in my experience “microplastics” is more often used. Something nano would be smaller than micro, a thousand times smaller if we’re using the metric system. Colloquially, nano may just be “quite a bit smaller” than micro. YouTube posted this video on Dec 3, 2025:

The speaker refers to a scientific article published at Nature Medicine on Feb 3, 2025: Bioaccumulation of microplastics in decedent human brains. Seems to me they should have used “nanoplastics” in the title instead of “microplastics.”

Not only are the microplastics allegedly bad for us, they are linked to “forever chemicals” which may mediate the badness. E.g., BPA-like chemicals (bisphenol A).

Are you worried about microplastics in your body?

Click this link to NRDC (National Resources Defense Council) for ten tips to keep plastic out of your body.

Katie Couric interviewed Dr. Matthew J Campen, one of the authors of the study referenced above and a toxicology professor at the University of New Mexico. He impresses me with the idea that his study’s findings are very preliminary and need verification by other labs, and that the implications for how we live today are not clear by any means. He speculates that the nanoplastics he finds in human tissue samples were ingested as nanoparticles that originated in landfills years ago. Discarded plastic waste deteriorated over time, breaking down to nanoparticles that contaminated groundwater and also ended up in agricultural products. Therefore, he suggests that there is not much individuals can do about avoiding nanoplastics except perhaps limiting meat consumption. Dr Campen notes that cutting down on our use of plastics now is more likely to help those a couple generations hence than to help us. He is highly skeptical about any current remedies that purport to remove nanoplastics from our tissues. Yet he suggests that our bodies may indeed have an intrinsic mechanism to reject (eject?) the particles.

Dr Campen does not impress me as a hair-on-fire bomb-thrower. Couric did and impressive job interviewing him.

I may start referring to freshly discarded plastics as macroplastics.

—–Steve Parker, M.D.

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Is War a Racket, Scam, Grift, Swindle, Con, or Cozenage?

U.S. Army AH-64 Apache” by Sergeant Matt Hecht/ CC0 1.0

Excerpt from a speech delivered in 1933, by Major General Smedley Butler, USMC:

War is just a racket. A racket is best described, I believe, as something that is not what it seems to the majority of people. Only a small inside group knows what it is about. It is conducted for the benefit of the very few at the expense of the masses.

I believe in adequate defense at the coastline and nothing else. If a nation comes over here to fight, then we’ll fight. The trouble with America is that when the dollar only earns 6 percent over here, then it gets restless and goes overseas to get 100 percent. Then the flag follows the dollar and the soldiers follow the flag.

I wouldn’t go to war again as I have done to protect some lousy investment of the bankers. There are only two things we should fight for. One is the defense of our homes and the other is the Bill of Rights. War for any other reason is simply a racket.

There isn’t a trick in the racketeering bag that the military gang is blind to. It has its “finger men” to point out enemies, its “muscle men” to destroy enemies, its “brain men” to plan war preparations, and a “Big Boss” Super-Nationalistic-Capitalism.

It may seem odd for me, a military man to adopt such a comparison. Truthfulness compels me to. I spent thirty- three years and four months in active military service as a member of this country’s most agile military force, the Marine Corps. I served in all commissioned ranks from Second Lieutenant to Major-General. And during that period, I spent most of my time being a high class muscle- man for Big Business, for Wall Street and for the Bankers. In short, I was a racketeer, a gangster for capitalism.

I suspected I was just part of a racket at the time. Now I am sure of it. Like all the members of the military profession, I never had a thought of my own until I left the service. My mental faculties remained in suspended animation while I obeyed the orders of higher-ups. This is typical with everyone in the military service.

I helped make Mexico, especially Tampico, safe for American oil interests in 1914. I helped make Haiti and Cuba a decent place for the National City Bank boys to collect revenues in. I helped in the raping of half a dozen Central American republics for the benefits of Wall Street. The record of racketeering is long. I helped purify Nicaragua for the international banking house of Brown Brothers in 1909-1912 (where have I heard that name before?). I brought light to the Dominican Republic for American sugar interests in 1916. In China I helped to see to it that Standard Oil went its way unmolested.

During those years, I had, as the boys in the back room would say, a swell racket. Looking back on it, I feel that I could have given Al Capone a few hints. The best he could do was to operate his racket in three districts. I operated on three continents.

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U.S. Healthcare: Does It Make Sense to Go Without Health Insurance?

You may learn something from this video by a bike repair shop owner.

If he foregoes health insurance, I recommend a Health Savings Account.

Steve Parker, M.D.

PS: Most of my books will help you safely avoid the medical-industrial complex.

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When His Lips Are Moving…

How can you tell when a politician is lying?

And yet we think politicians can reform U.S. healthcare in a beneficial direction…

Steve Parker, M.D.

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This Is No Way to Treat People

Don’t watch the video if you’re not ready for a sad, sad, story about a cancer patient. Non-U.S. citizens may not understand this story.

Steve Parker, M.D.

PS: I can neither defend nor criticize the specific cancer treatment discussed in the video. I don’t know enough about the case and, compared with an oncologist, I know very little about cancer treatment.

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RIP: Dr Richard Bernstein, Diabetes Treatment Pioneer

Dr Bernstein passed on to his reward last April. He was a major influence on my own approach to diabetes treatment. We see very few “great men” in our times: He was one.

Dr Bernstein practiced what he preached, which explains how he lived to the age of 90. That is exceedingly rare for a type 1 diabetic.

Thanks to Jan at The Low Carb Diabetic for bringing this to my attention. She published an account of what it was like to be one of Dr Bernstein’s patients.

Steve Parker, M.D.

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A Modern History of the Diet-Heart Hypothesis

Heart attacks and chest pains are linked to blocked arteries in the heart

It was around 2009 when I was finally ready to abandon the time-honored diet-heart hypothesis. I remember wondering if I’d be excommunicated from the medical community, i.e., lose my medical license due to heresy. In a nutshell, the diet-heart hypothesis to which I refer was the idea that dietary saturated fat was the clear-cut cause of coronary artery disease and associated heart attacks, angina pectoris (reversible heart pains), and cardiac deaths. (Also strokes and peripheral arterial disease.)

My re-evaluation of the evidence lead me to create the world’s first ketogenic Mediterranean diet, which is included in the 2nd edition of my Advanced Mediterranean diet and Conquer Diabetes and Prediabetes. Search Amazon.com and you’ll find several other subsequent ketogenic Mediterranean diet books; I wonder if any of them cited my work.

Dr. Axel Sigurdsson recently wrote an updated history of the diet-heart hypothesis, focusing on the downfall of the hypothesis and the role of George Mann, whom I’d swear I never heard of. An excerpt:

Ancel Keys changed the world. He was right about many things—that lifestyle matters, that food affects disease, that public health can’t afford to wait forever. But in boiling heart disease down to a single nutrient, he oversimplified a complex truth. His hypothesis became policy before it was fully proven. And once policy hardens, it resists correction.

George Mann was no savior. His critiques were often bombastic, his tone combative. But beneath the fire was a warning science should have heeded: that premature consensus can blind, that evidence must lead—not politics, not personalities, not the noise of institutional momentum.

I recommend the entire article to you. I suspect AI (artificial intelligence) was utilized, mainly judging from the three pictures. Dr. Sigurdsson has been publishing some great articles recently, and I believe credited AI in some of them, which is OK by me.

Steve Parker, M.D.

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Shocking Study Reveals mRNA Vaccine Risks: Higher Rates of Brain Disorders

Alleged attorney Jeff Childers reports an alleged link between the covid-19 vaccine(s) and neuropsychiatric disorders. The item starts a third of the way down the web page. I haven’t read the source article and probably won’t. You’ll see mention below of cerebral venous sinus thrombosis. One of the neurologists I work with has started ordering more brain scans looking for that. Coincidence?

All that follows is from Childers. To facilitate readability, I won’t put it in italics like I usually do quotations:

For years, scientists who questioned mRNA safety were told to put up or shut up (“publish or perish”). Well— now they’ve published. And I’ll give you one guess whether or not the conclusions support our long-standing concerns. Today, a new peer-reviewed study published in the International Journal of Innovative Research in Medical Science, blandly titled “View of Association Between COVID-19 Vaccination and Neuropsychiatric Conditions.

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The results, however, were not bland.

In the just-published peer-reviewed study, researchers analyzed over three decades of vaccine injury reports in the U.S. government’s own VAERS database, comparing covid mRNA vaccines to both flu shots and all other vaccines (combined). Using the CDC’s and FDA’s own method for detecting safety problems —called “Proportional Reporting Ratios” or PRRs— they found that reports of serious neuropsychiatric issues like brain fog, psychosis, dementia, and even suicidal behavior were not just higher, but dozens to hundreds of times more frequent after the covid shots.

If you thought people were crazy to take the jab, you might have been onto something.

The safety signal thresholds weren’t just crossed; they were blown out of the water, with some categories showing PRRs over four hundred, far above the FDA’s red-flag threshold of two. The study concluded these signals were sufficiently alarming to warrant immediate attention and further investigation— an understatement as big as the Statue of Liberty.

Among the most alarming findings, the study flagged massive spikes in reports of serious brain-related problems after covid vaccination. Compared to flu shots, reports of brain fog were up over 100-fold, psychosis nearly 80 times higher, and Alzheimer’s-type dementia more than 40 times more frequent. Even more chilling, reports related to suicidal thoughts or behaviors, including suicide attempts and self-harm, showed increases as high as 80-fold. One rare but deadly condition —cerebral venous sinus thrombosis, a type of brain clot— was reported at rates over 400 times higher than with flu vaccines.

These numbers weren’t small deviations— they were sky-high red flags by the FDA’s own data and safety standards.


Steve Parker, M.D.

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Why I Rarely Read Medical Journals

When I was doing my Internal Medicine residency in 1981 to 1984, we held scientific medical journals in great esteem. The New England Journal of Medicine, for instance. It was published once weekly, about a hundred pages IIRC. At the end of the year, I sent my 52 copies off to a bindery to be glued into a hard-cover book format, to be cherished and consulted for years. That book was two or three inches thick. I did that for maybe five consecutive years; I’ve no idea where they are now. Probably in a landfill.

The told us on the first day of medical school, “Half of what we teach you will be obsolete in five years.” So continuing medical education is an imperative. One way to keep learning is to read medical journals.

You may be surprised to learn that I no longer read scientific medical journals very often. How do I keep my medical practices up to date? I work in the hospital side-by-side with surgeons and medical subspecialists (e.g., cardiologists, gastroenterologists). In general, I talk to them and watch what they do. If there is a ground-breaking new diagnostic tool or therapy, I’ll hear about it from them. They’re not in an ivory tower, isolated from patients. They’re in the trenches with me facing sick and hurting patients every day. I still read scientific medical journals, but take them with a nugget of salt.

I’m a science journal skeptic, questioning their reliability, objectivity, and relevance. But I’m not the only won. Check out the writings of Dr. Marcia Angell, former editor of New England Journal of Medicine, and Dr. John Ioannidis.

Seemay Chou had this to say about scientific journals:

I’m a scientist. Over the past five years, I’ve experimented with science outside traditional institutes. From this vantage point, one truth has become inescapable. The journal publishing system — the core of how science is currently shared, evaluated, and rewarded — is fundamentally broken. 

Vox Day has excerpted a TLDR from Chou’s article:

It might seem like publishing is a detail. Something that happens at the end of the process, after the real work of science is done. But in truth, publishing defines science.

The currency of value in science has become journal articles. It’s how scientists share and evaluate their work. Funding and career advancement depend on it. This has added to science growing less rigorous, innovative, and impactful over time. This is not a side effect, a conspiracy, or a sudden crisis. It’s an insidious structural feature.

For non-scientists, here’s how journal-based publishing works:

After years of research, scientists submit a narrative of their results to a journal, chosen based on field relevance and prestige. Journals are ranked by “impact factor,” and publishing in high-impact journals can significantly boost careers, visibility, and funding prospects.

Journal submission timing is often dictated by when results yield a “publishable unit” — a well-known term for what meets a journal’s threshold for significance and coherence. Linear, progressive narratives are favored, even if that means reordering the actual chronology or omitting results that don’t fit. This isn’t fraud; it’s selective storytelling aimed at readability and clarity.

Once submitted, an editor either rejects the paper or sends it to a few anonymous peer reviewers — two or three scientists tasked with judging novelty, technical soundness, and importance. Not all reviews are high quality, and not all concerns are addressed before editorial acceptance. Reviews are usually kept private. Scientific disagreements — essential to progress — rarely play out in public view.

If rejected, the paper is re-submitted elsewhere. This loop generally takes 6–12 months or more. Journal submissions and associated data can circulate in private for over a year without contributing to public discussion. When articles are finally accepted for release, journals require an article processing fee that’s often even more expensive if the article is open access. These fees are typically paid for by taxpayer-funded grants or universities.

Several structural features make the system hard to reform:

  • Illusion of truth and finality: Publication is treated as a stamp of approval. Mistakes are rarely corrected. Retractions are stigmatized.
  • Artificial scarcity: Journals want to be first to publish, fueling secrecy and fear of being “scooped.” Also, author credit is distributed through rigid ordering, incentivizing competition over collaboration. In sum, prestige is then prioritized.
  • Insufficient review that doesn’t scale: Three editorially-selected reviewers (who may have conflicts-of-interest) constrain what can be evaluated, which is a growing problem as science becomes increasingly interdisciplinary and cutting edge. The review process is also too slow and manual to keep up with today’s volume of outputs.
  • Narrow formats: Journals often seek splashy, linear stories with novel mechanistic insights. A lot of useful stuff doesn’t make it into public view, e.g. null findings, methods, raw data, untested ideas, true underlying rationale.
  • Incomplete information: Key components of publications, such as data or code, often aren’t shared to allow full review, reuse, and replication. Journals don’t enforce this, even for publications from companies. Their role has become more akin to marketing.
  • Limited feedback loops: Articles and reviews don’t adapt as new data emerges. Reuse and real-world validation aren’t part of the evaluation loop. A single, shaky published result can derail an entire field for decades, as was the case for the Alzheimer’s scandal.

Stack all this together, and the outcome is predictable: a system that delays and warps the scientific process. It was built about a century ago for a different era. As is often the case with legacy systems, each improvement only further entrenches a principally flawed framework.


Steve Parker, M.D.

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