September 12, 2011 · 12:09 PM

Insulin Resistance, Lipotoxicity, Type 2 Diabetes, and Atherosclerosis

This will bore most readers.

I just want to mention a scientific review article from 2009 that reviews insulin activity (down to a molecular level) in the context of type 2 diabetes, atherosclerosis, and insulin resistance.  Towards the end it starts sounding like an informercial for thiazolidinedione drugs. 

The author makes a great case for the dangers of hyperinsulinemia.

Good reference overall.

R. A. DeFronzo wrote “Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009.”   Diabetologia, 2010 (53); 1,270-1,287.  doi: 10.1007/s00125-010-1684-1

Steve Parker, M.D.

1 Comment

Filed under Causes of Diabetes, coronary heart disease

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One response to “Insulin Resistance, Lipotoxicity, Type 2 Diabetes, and Atherosclerosis”

  1. liposuction
    February 10, 2012 at 7:07 PM

    According to the latest statistic from National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), there are 25.8 million people of all ages (8.3% of United States population) affected by diabetes. Out of 25.8 million diabetes patients, about 90% of them are having Type 2 Diabetes which is because of insulin resistance.