Diabetes + Overweight and Obesity = Diabesity

Mark Hyman, M.D., blogged about diabesity at the Huffington Post December 24, 2009.  He defines diabesity as a problem with glucose regulation associated with overweight and obesity.  The glucose physiology problem ranges from metabolic syndrome to prediabetes to full-blown type 2 diabetes.

“Diabesity” has been in circulation for a few years, but hasn’t caught on yet. 

What interested me about his blog post was that he advocates the Mediterranean diet as both therapeutic and prophylactic.  To quote Dr. Hyman:

The optimal diet to prevent and treat diabesity includes:

  • Fruits
  • Vegetables
  • Nuts
  • Seeds
  • Beans
  • Whole grains
  • Healthy fats such as olive oil, nuts, avocados, and omega-3 fats
  • Modest amounts of lean animal protein including small wild fish such as salmon or sardines

This is commonly known as a Mediterranean diet.  It is a diet of whole, real, fresh food. It is a diet of food you have to prepare and cook from the raw materials of nature.  And it has broad-ranging benefits for your health.

Food for thought, no doubt. 

Steve Parker, M.D.

Reference:  Hyman, Mark.  The diabesity epidemic part III:  Treating the real causes instead of the symptoms.  The Huffington Post, December 24, 2009

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Filed under Causes of Diabetes, Fish, Fruits, Grains, legumes, nuts, Overweight and Obesity, Prevention of T2 Diabetes

Recipe: Low-Carb Chili

I made this chili last night for the family.  It’s spicy, but not hot spicy.  Sliced and peeled cold cucumbers are a nice side dish.  The kids are not eating low-carb; they enjoyed the chili mixed 50:50 with cheese macaroni, and buttered cornbread on the side.      

Ingredients

20 oz  Ground beef, 80% lean meat/20% fat, raw

20 oz  Sausage, Italian, pork, raw

1  Onion, large, raw 

14.5 oz  Tomatoes, canned, diced

4 oz  Tomato paste 

1 tbsp  Cocoa powder, dry, unsweetened

5  Garlic cloves, raw

1/2 tsp  Salt

1/4 tsp  Allspice, ground

2 tbsp  Chili powder

1/4 tsp Cinnamon, ground

0.5 tbsp Cumin, ground 

1/4 tsp Cayenne pepper, ground

2 packets  Splenda sweeteners (packet is 1 g)

 1 cup  Water

Preparation

Cut the Italian suasage into small pieces.  Fry the sauage, ground beef, onions, and garlic in a large pot.  Don’t just brown the meat: cook it thoroughly.  When done, drain off the fat if desired.  Add the remainder of ingredients, bring to a boil, then simmer for about an hour.  Add additional water if the chili looks too thick.  Makes eight cups.  Serving size is one cup. 

Nutrient Analysis (compliments of NutritionData.com)

One cup serving:  492 calories.  10% of calories from carbohydrate, 69% from fat, 21% from protein.  Total fat 38 g.  Total protein 24 g.  Total carbohydrate 14 g.  Fiber 3 g.  Digestible carbohydrate 11 g.  Percent Daily Values: 23% of vitamin A, 28% of vitamin C, 21% of iron. 

Notes: Analysis is based on fat not being drained from the cooked meat.  Calorie count and calories from fat would be a bit lower if you drained off fat.

Steve Parker, M.D.

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What Are Phytonutrients and What Have They Done For Me Lately?

Nutrition scientists think that plants have small amounts of numerous “bioactive compounds,” sometimes referred to as phytonutrients, that protect us against disease.

Many scientific studies have looked at groups of people over time, noting the various foods they eat as well as the diseases they develop.  These are called epidemiologic, ecological, or observational studies.  One finding is that lower rates of heart disease, vascular disease, and cancer are seen in people consuming plant-based diets.  “Plant-based” isn’t necessarily vegetarian or vegan.  The traditional Mediterranean diet, for example, is considered by many to be plant-based because meat, fish, and poultry are not prominent compared to plants. 

In contemplating what source of carbohydrates a person with diabetes should eat, I’ve been reviewing the scientific literature to see which sources of carbs might provide the biggest bang for the buck in terms of health and longevity benefits.

Here are some quotes from a 2002 review article in the American Journal of Medicine:

Phenolic compounds, including their subcategory, flavonoids, are present in all plants and have been studied extensively in cereals, legumes, nuts, olive oil, vegetables, fruits, tea, and red wine. Many phenolic compounds have antioxidant properties, and some studies have demonstrated favorable effects on [blood clotting] and [growth of tumors]. Although some epidemiologic studies have reported protective associations between flavonoids or other phenolics and cardiovascular disease and cancer, other studies have not found these associations.

Hydroxytyrosol, one of many phenolics in olives and olive oil, is a potent antioxidant.

Resveratrol, found in nuts and red wine, has antioxidant, [anti-blood-clotting], and anti-inflammatory properties, and inhibits [malignant tumor onset and growth].

Lycopene, a potent antioxidant carotenoid in tomatoes and other fruits, is thought to protect against prostate and other cancers, and inhibits tumor cell growth in animals.

Organosulfur compounds in garlic and onions, isothiocyanates in cruciferous vegetables, and monoterpenes in citrus fruits, cherries, and herbs have [anti-cancer] actions in experimental models, as well as [heart-healthy effects].

In summary, numerous bioactive compounds appear to have beneficial health effects. Much scientific research needs to be conducted before we can begin to make science-based dietary recommendations. Despite this, there is sufficient evidence to recommend consuming food sources rich in bioactive compounds. From a practical perspective, this translates to recommending a diet rich in a variety of fruits, vegetables, whole grains, legumes, oils, and nuts.

The article discusses phytoestrogens—plant chemicals that act in us like the female hormone estrogen—but effects are complex and I suspect we know much more now than we did in 2002 .  Soy products are the most well-known source of phytoestrogens.

The traditional Mediterranean diet is rich in all of the foods mentioned above, except for tea.  Even the Ketogenic Mediterranean Diet includes the aforementioned foods except for tea (I need to add tea and coffee), cereals, and cherries.

Steve Parker, M.D.

Reference:  Kris-Etherton, P.M., et al.  Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer.  American Journal of Medicine, 113 (2002. Supplement 9B): 71S-88S.

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Filed under cancer, coronary heart disease, Fruits, Grains, Health Benefits, legumes, Mediterranean Diet, nuts, olive oil

Book Review: Cheating Destiny – Living With Diabetes, America’s Biggest Epidemic

I read James Hirsch’s book in 2006 but never got around to reviewing it.  Better late than never?  I give it four stars per Amazon.com’s rating system: “I like it.”

♦   ♦   ♦

Cheating Destiny: Living With Diabetes, America's Biggest EpidemicIf you have diabetes or love someone who is afflicted by diabetes, you’ll benefit from this book. It’s an insider’s view into the world of diabetes, with a predominant focus on type 1 rather than type 2.  Both are covered well.

Look elsewhere for a “how-to” book on managing diabetes.  Cheating Destiny is about emotions, coping strategies, public policy, and history.  Although I’ve been treating diabetes for over two decades, Mr. Hirsch taught me a thing or two.  For instance, did you know . . . that some people with diabetes are offended if you call them diabetics? (They prefer “people with diabetes.”)  That diabetes was considered shameful years ago?  That even the preeminent Joslin Diabetes Clinic loses money and has to be supported by private donations?  That the founder of d-Life TV was a patient of the iconoclastic Dr. Richard Bernstein?  About the exciting story of the discovery of insulin by Fred Banting and Charles Best in 1922?   

The author himself has type 1 diabetes.  The heart-wrenching story of his son’s diagnosis at age 3 showcases Mr. Hirsch’s considerable writing skills. 

To counter the sad and frustrating aspects of diabetes, the book is peppered with  funny anecdotes.  Did you ever duck in to a private booth at a girlie peep show to inject insulin?  Mr. Hirsch has!  [It’s not what you think.]

One undercurrent of the book I take issue with is the implication that the medical profession somehow perpetuates diabetes or purposefully provides inadequate care, because that’s where the money is.  Why work hard to cure diabetes or prevent complications when the profession makes money off the disease and it’s complications?  I don’t see it that way at all.  It is true, however, that preventive care and cognitive medical services (as opposed to invasive procedures) are poorly funded by insurance.  That’s an economic and political problem, not an ethical one in physicians and researchers.
 
Full disclosure:  My defunct outpatient medical practice is mentioned in chapter five.  The author outlines my efforts to provide conscientious care to people with diabetes – mostly type 2 – despite poor funding from insurers (primarily Medicare in my practice at the time).  Poor pay for cognitive services forced me to close my office.  I found Mr. Hirsch to be a thorough and accurate researcher.

[I’m a hospitalist and health blogger now.]

Other highlights of the book are discussions of Dr. Elliott Joslin, an overweight Southern black woman (the Diabetes Queen), intimate details about the type 1 diabetes experience from the patient and family perspective, Dr. Richard Bernstein, insulin pumps, islet cell transplants, origins of the Juvenile Diabetes Research Foundation, Douglas Melton and stem cell research, research rivalries and funding, and inspirational survivor tales.

Mr. Hirsch rightfully criticizes many aspects of the health and medical fields with regards to diabetes.  Thankfully, he never suggests a sweeping government take-over of the healthcare industry.  He urges diabetics – people with diabetes – to take care of their own disease and demand improvements in the current system.

The U.S. already has 24 million people with diabetes and another 54 million with prediabetes.  Approximately one of every three persons born in the U.S. in 2000 will develop diabetes in his or her lifetime, according to the Centers for Disease Control and Prevention.

I agree with Mr. Hirsch that diabetes is “the country’s leading public health crisis,” driven by obesity and the aging of the population.”  This book will help alleviate the damages. 

Steve Parker, M.D.

Disclosure:  I bought this book at Amazon.com.  I was not paid to review it.

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Legumes and Whole Grains: Any Role in Diabetes?

Expert nutrition panels consistently recommend whole grains and legumes for people with diabetes.  Why?  And do these foods affect development of diabetes?  I found a pertinent scientific review article on the subject from 2004 in the European Journal of Clinical Nutrition.  Here are some pertinent quotes from the summary:

Epidemiological studies strongly support the suggestion that high intakes of whole grain foods protect against the development of type II diabetes mellitus (T2DM). People who consume approximately 3 servings per day of whole grain foods are less likely to develop T2DM than low consumers (<3 servings per week) with a risk reduction in the order of 20-30%.

The role of legumes in the prevention of diabetes is less clear, possibly because of the relatively low intake of leguminous foods in the populations studied. However, legumes share several qualities with whole grains of potential benefit to glycaemic control including slow release carbohydrate and a high fibre content. A substantial increase in dietary intake of legumes as replacement food for more rapidly digested carbohydrate might therefore be expected to improve glycaemic control and thus reduce incident diabetes. This is consistent with the results of dietary intervention studies that have found improvements in glycaemic control after increasing the dietary intake of whole grain foods, legumes, vegetables and fruit.

. . . it is cereal fibre that is largely insoluble [rather than soluble fiber] that is associated with a reduced risk of developing T2DM.

Thus, there is strong evidence to suggest that eating a variety of whole grain foods and legumes is beneficial in the prevention and management of diabetes. This is compatible with advice from around the world that recommends consumption of a wide range of carbohydrate foods from cereals, vegetables, legumes and fruits both for the general population and for people with diabetes.

Gluten Intolerance

A major protein in wheat is gluten.  The last few years have seen the popular emergence of gluten-free this and gluten-free that.  The idea is that gluten causes a variety of gastrointestinal, immunologic, and other problems, so wheat products should be avoided.  Certainly they should be avoided in people with celiac disease, a well-established medical condition.  I follow a few paleo blogs and know that grains and legumes are not part of that way of eating: the paleos say we are not evolved optimally to process them.    

If legumes or wheat or other grains cause problems for you, don’t eat them.  They have no essential nutrients that you can’t get elsewhere. 

Glycemic Index

In my quest to develop a healthy Diabetic Mediterranean Diet, I’m finding that grains—compared to nearly all other carbohydrate-containing food groups—tend to have a higher glycemic index (GI).   A low GI is 55 or less.  High GI is 70 or greater.  Grains in general raise blood sugar levels higher than many other sources of carbohydrates.  But this is highly variable and depends partially on preparation of the grain.  Whole grain products have a lower GI than highly processed counterparts.  For instance, white bread has a GI of 70; whole wheat bread 67.  Regular spaghetti is 38.  Table sugar’s GI must be sky high, right?  No, its just 61.  A baked potato is a whopping 85.   

Beans have a GI around 30 or 40.  And they pack a lot more fiber per serving.  For a diabetic struggling to keep blood sugars under control, which is a better choice: grains or legumes?  I’m leaning towards legumes and other components of a low-glycemic-index diet.   

Steve Parker, M.D.

PS:  [Before you correct my GI numbers, please note I’m  aware that various GI lists don’t agree with each other.]

Reference:  Venn, B.J. and Mann, J.I. Cereal grains, legumes and diabetes.  European Journal of Clinical Nutrition, 58 (2004): 1,443-1,461.

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Filed under Fiber, Fruits, Grains, legumes, Prevention of T2 Diabetes, Vegetables

One of Every Three Born in 2000 Will Develop Diabetes

"No diabetes in my future!"

The U.S. already has 24 million people with diabetes and another 54 million with prediabetes.  Approximately one of every three persons born in the U.S. in 2000 will develop diabetes in his or her lifetime, according to the Centers for Disease Control and Prevention.

Incredible.

And largely preventable if we have the will.

Steve Parker, M.D.

Reference: Prediabetes FAQs at the CDC website.

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Do Fruits and Vegetables Really Help Prevent Disease?

How many times have you heard how important it is to eat fruits  and vegetables?  Now, is it five or nine servings a day?  Why are fruits and veggies always lumped together?  What does a watermelon have in common with spinach?

The author of a 2004 article in the Journal of Postgraduate Medicine answered some of these questions.  Here are a few quotes from from the summary:

The intake of 400-600 g/d of fruits and vegetables is associated with reduced incidence of many common forms of cancer, and diets rich in plant foods are also associated with a reduced risk of heart disease and many chronic diseases of ageing.

These foods contain phytochemicals that have anti-cancer and anti-inflammatory properties which confer many health benefits. Many phytochemicals are colourful, and recommending a wide array of colourful fruits and vegetables is an easy way to communicate increased diversity of intake to the consumer. For example, red foods contain lycopene, the pigment in tomatoes, which is localized in the prostate gland and may be involved in maintaining prostate health, and which has also been linked with a decreased risk of cardiovascular disease. Green foods, including broccoli, Brussels sprouts and kale, contain glucosinolates which have also been associated with a decreased risk of cancer. Garlic and other white-green foods in the onion family contain allyl sulphides which may inhibit cancer cell growth. Other bioactive substances in green tea and soybeans have health benefits as well.

Consumers are advised to ingest one serving of each of the seven colour groups daily, putting this recommendation within the United States National Cancer Institute and American Institute for Cancer Research guidelines of five to nine servings per day. Grouping plant foods by colour provides simplification, but it is also important as a method to help consumers make wise food choices and promote health.

Asking U.S. consumers to eat one serving from each of seven fruit and vegetable color groups daily is a bit much.  I don’t see that happening.  But the suggestion is a start.  Darya Pino (Summer Tomato blog) probably does it every day, but I don’t know any others.  My simplified message: Eat a variety of colorful fruits and veggies daily.

Note that the very low-carb Ketogenic Mediterranean Diet provides 400 grams of vegetables and fruits daily, and I count seven colors (assuming you allow me to include black olives).  On the KMD document I list avocado, cucumber, and tomato under “vegetables,” but they are indeed fruits.  Heck, I guess olives are fruit, too.

“So, what’s your point, Parker,” you might well ask.  I don’t expect anyone to follow the Ketogenic Mediterranean Diet for life.  When it’s time to move on to a “Diabetic Mediterranean Diet,” I’m considering adding more options: traditional fruits and some colorful vegetables like purple beets, yellow corn, and orange carrots and sweet potatoes.

I still don’t know why “fruits and vegetables” are joined at the hip.  Legumes, grains, and dairy products all rate their very own category.  It’s just not fair.

Steve Parker, M.D.

Reference:  Heber, D.  Vegetables, fruits and phytoestrogens in the prevention of diseases.  Journal of  Postgraduate Medicine, 50 (2004): 145-9.

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Legumes and Cereal Grains: Any Role in Weight Management?

Researchers at the University of Wollongong (Australia) reviewed the scientific literature on the role for cereal grains and legumes in weight management.

In this context, “cereal” refers to “a grass such as wheat, oats, or corn, the starchy grains of which are used as food” (American Heritage Dictionary). 

Here’s their summary:

There is strong evidence that a diet high in whole grains is associated with lower body mass index, smaller waist circumference, and reduced risk of being overweight; that a diet high in whole grains and legumes can help reduce weight gain; and that significant weight loss is achievable with energy-controlled diets that are high in cereals and legumes. There is weak evidence that high intakes of refined grains may cause small increases in waist circumference in women. There is no evidence that low-carbohydrate diets that restrict cereal intakes offer long-term advantages for sustained weight loss. There is insufficient evidence to make clear conclusions about the protective effect of legumes on weight.  

I haven’t read the entire article, but invite you to do so.  I’m searching for clues as to which type of carbs to add after one finishes the Ketogenic Mediterranean Diet.

Steve Parker, M.D.

Reference:  Williams, P.G., et al.  Cereal grains, legumes, and weight management: a comprehensive review of the scientific evidence.  Nutrition Reviews, 66(2008): 171-82.

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Book Review: The Blue Zones

Here’s my review of  The Blue Zones: Lessons for Living Longer From the People Who’ve Lived the Longest, a 2008 book by Dan Buettner.  I give the book four stars on Amazon.com’s five-star system (“I like it”). 

♦   ♦   ♦

The lifestyle principles advocated in The Blue Zones would indeed help the average person in the developed world live a longer and healthier life.  The book is a much-needed antidote to rampant longevity quackery.  Dan Buettner’s idea behind the book was “discovering the world’s best practices in health and longevity and putting them to work in our lives.”  He succeeds. 

Mr. Buettner assembled a multidisciplinary team of advisors and researchers to help him with a very difficult subject.  Do people living to 100, scattered over several continents, share any characteristics?  Do those commonalities lead to health and longevity? 

They studied four longevity hot spots (Blue Zones):

  • Okinawa islands (Japan)
  • Barbagia region of Sardinia (an island off the Italian mainland)
  • Loma Linda, California (a large cluster of Seventh Day Adventists)
  • and the Nicoya Peninsula (Costa Rica). 

Research focused on people who lived to be 100. 

Until recently, two of the Blue Zones—the Nicoyan Peninsula and Sardinia—were quite isolated, with relatively little influence from the outside world. 

Mr. Buettner et al identify nine key traits that are associated with longevity and health in these cultures.  Of course, association is not causation, which Mr. Buettner readily admits.  He draws more conclusions from the data than would many (most?) longevity scientists.  Scientists can wait for more data, but the rest of us have to decide and act based on what we know today.  Here are the “Power Nine”:

  1. regular low-intensity physical activity
  2. hari hachi bu (eat until only 80% full—from Okinawa)
  3. eat more plants and less meat than typical Western cultures
  4. judicious alcohol, favoring dark red wine
  5. have a clear purpose for being alive (a reason to get up in the morning, that makes a difference)
  6. keep stress under control
  7. participate in a spiritual community
  8. make family a priority
  9. be part of a tribe (social support system) that “shares Blue Zone values”

Of these, I would say the available research best supports numbers 1, 4, 7, 8, and the social support system.

I doubt that hari hachi bu (eat until you’re only 80% full) will work for us in the U.S.  It’s never been tested rigorously.  The idea is to avoid obesity.  

The author believes that average lifespan could be increased by a decade via compliance with the Power Nine.  And these would be good, relatively healthy years.  Not an extra 10 years living in a nursing home.

Appropriately and early on, Mr. Buettner addresses the issue of genetics by mentioning a single study of Danish twins that convinces him longevity is only 25% deterimined by genetic heritage.  Environment and lifestyle choices determine the other 75%.  I believe he underestimates the effect of genetics. 

Over half the population of the Nicoya Peninsula Blue Zone are of Chorotega Indian descent, not from Spanish Conquistadores.  Would a Danish twin study have much tosay about Chorotega Indians’ longevity?  We don’t know, but I’m skeptical.  Also, the Sardinians and Okinawans would seem to have centuries of a degree of inbreeding, too, according to Buettner’s own documentation. 
 
Do the Adventists tend to marry and breed with each other (like Mormons), thereby concentrating longevity genes?  You won’t find the question addressed in the book.

Because I think genetics plays a larger role in longevity than 25%, I’d estimate that the healthy lifestyle choices in this book might prolong life by six or seven years instead of 10.  But I’m splitting hairs.  I don’t have any better evidence than Mr. Buettner, just a hunch plus years of experience treating diseased and dying patients.

These four Blue Zones do share a mostly plant-based diet of natural foods with minimal processing.  Two of the populations—the Okinawans and Costa Ricans—didn’t seem to have any choice.  Heavy meat consumption just wasn’t an option available to them.  Rather than promoting a low-meat plant-based diet, it might be more accurate to conclude that “you don’t have to eat a lot of meat, chicken, or fish to live a long healthy life.”

In other words, it may not matter how much meat you eat as long as you eat the healthy optimal level of fruits, vegetables, and whole grains.  It’s a critical difference not addressed in this book except among the Adventists.

Even if you could live an extra two years as a vegan, I’m sure many people would choose to eat meat anyway.  By the way, this book conflates vegan, lacto-vegetarian, lacto-ovo vegetarian, near-vegetarian, and vegetarian into one: vegetarian.  It’s a common problem when considering the health aspects of vegetarianism.  They are not necessarily the same.   

By the same token, plenty of my patients have told me they don’t like any kind of exercise and they won’t do it, even if it would give them an extra two years of life.  What many don’t realize is that from a functional standpoint, regular exercise makes their bodies perform as if they were ten years younger.  There’s a huge difference between the age of 80 and 70 in terms of functional abilities.

Why read the book now that you have the Power Nine?  To convince you to change your unhealthy ways, and indispensible instruction on how to do so.

Steve Parker, M.D.

Disclosure:  The publisher’s representative did not pay me for this review, nor ask for a favorable review.  They offered me a review copy and three give-aways, and I accepted.  I figure the cost of the books to the publisher was $16 USD total.  I gave away the books through my Advanced Mediterranean Diet Blog.  Cost of shipping the books to the winners came out of my pocket.

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New Year’s Traditions and Superstitions

Eat black-eyed peas on New Year’s Day for good luck in the coming year, at least if you live in the southern U.S. where I grew up.  In the Deep South, add pork and collard greens.

In some parts of Italy they eat lentils instead, for financial prosperity.  Lentils look  a bit like coins. 

In Greece, January 1 is St. Basil’s day.  He was the forefather of the Greek Orthodox church.  At midnight on New Year’s eve, the head of the household cuts vassilopitta (St. Basil’s cake).  Whoever gets the piece with the embedded silver or gold coin will be lucky for the next year. 

In Spain and Portugal, they eat 12 grapes, one grape at each stroke of the clock or bell at midnight New Year’s eve.  Assuming you don’t choke, you gain 12 months of prosperity and luck. 

Inhabitants in some regions of Portugal eat salt cod on New Year’s eve for good luck. 

In Mexico, if someone gives you red underwear and you have it on at midnight New Year’s eve, you’ll experience love that year.  Yellow underwear brings a good job, work, or prosperity.  Carry suitcases outside and around your house at midnight, and you’ll travel in the coming year.

My children were born in Pensacola, Florida—the Deep South for sure.  I’m picking up a can of black-eyed peas today. 

Here’s wishing you a happy and healthy New Year!

Steve Parker, M.D.

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