Tag Archives: lifespan

R.I.P., Mary Tyler Moore

Actress Mary Tyler Moore died today at the age of 80. She is probably the most famous type 1 diabetic of a certain generation, those watching TV in the 1960s and 1970s. According to her NYT obituary, her diabetes started in her 30s.

Average life expectancy in the U.S. is 78.8 years, based on 2014 data. It’s longer for women, shorter for men. That average is reduced by 10–12 years for those with type 1 diabetes.

It still amazes me that one of the very first users of insulin injections, Elizabeth Hughes, lived to be 73, having started insulin around age 22.

Steve Parker, M.D.

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Is Grape Seed Extract as Healthful as Wine?

Patients ask me periodically if grape seed extract provides the same health benefit as judicious red wine.  Nobody knows with certainty.  The health benefits of red wine may be due to resveratrol.  Grape seed extract contains potentially healthy antioxidants called proanthocyanidins,

Many people don’t enjoy wine or other alcohol-containing drinks, and others just shouldn’t drink any alcohol.  Should they take a grape seed extract supplement or drink grape juice as a subsitute?  Again, it’s still unclear.  In 2009 I wrote a about a review article looking at the effect of various non-wine grape products and effects on heart disease risk.

A recent meta-analysis out of the University of Connecticut found improvement in two heart disease risk factors in those who take a grape seed extract supplement:

  • systolic blood pressure lower by 1.54 mmHg
  • heart rate lower by 1.42 beats per minute

No effect was seen on lipids (cholesterol and triglycerides), diastolic blood pressure, and C-reactive protein (a test of systemic inflammation).

Granted, these are tiny effects.  It’s unknown whether they, or other unknown effects of grape seed extract, would translate into clinical benefits such as fewer heart attacks and strokes, and longer lifespans.

Bottom Line

Grape seed extract and other non-wine grape products may be as beneficial as red wine in prolonging lifespan and preventing heart disease.  But we have much stronger evidence in favor of red wine and other alcohol-containing drinks.

Steve Parker, M.D.

 Reference:  Feringa, H.H.H, et al. The Effect of Grape Seed Extract on Cardiovascular Risk Markers: A Meta-Analysis of Randomized Controlled TrialsJournal of the American Dietetic Association, 111 (2011): 1,173-1,181.

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Diabetes and Shortened Lifespan: “How Bad Is It, Doc?”

Diabetes mellitus for years has been linked with cardiovascular disease such as heart failure and coronary heart disease (blocked arteries in the heart, and the leading cause of death in the Western world).  How scared should diabetics be?

An article  in the Archives of Internal Medicine gives us one answer.

Researchers from the Netherlands and Harvard examined medical records of 5,209 people (mostly white, 64% men) enrolled in the Framingham (Massachusetts, USA) Heart Study.  This cohort has been examined every other year for more than 46 years. 

Study subjects who had diabetes at age 50 were identified; health outcomes going forward were then analyzed, with particular attention to lifespan and cardiovascular disease.  “Cardiovascular disease” in this context means coronary heart disease, stroke, congestive heart failure, intermittent claudication (leg pain during exertion caused by blocked arteries), and transient ischemic attack (stroke-like symptoms that resolve within 24 hours).

Results

Compared to those in the cohort free of diabetes, having diabetes at age 50 more than doubled the risk of developing cardiovascular disease for both women and men. 

Compared to those without diabetes, having both cardiovascular disease and diabetes approximately doubled the risk of dying, regardless of sex.

Compared to those without diabetes, women and men with diabetes at age 50 died 7 or 8 years earlier, on average.

[Specific causes of death were not reported.]

Take-Home Points

We’d likely see longer lifespans and less cardiovascular disease if we could prevent diabetes in the first place.  How do we do that?  Strategies include regular physical activity, avoidance or reversal of overweight and obesity, and low-glycemic-index diets.

The Mediterranean diet it linked to reduced heart attacks and strokes, and longer lifespan.  That’s why I’ve been working for the last year and a half to adapt it for diabetics.

ResearchBlogging.orgWe have better treatments for cardiovascular disease and diabetes and these days, so the death rates and illness numbers shouldn’t  be quite so alarming.  Up-to-date management of diabetes and cardiovascular disease will prevent some acute disease events—such as heart attacks and strokes—and prolong life.   

Steve Parker, M.D.

References: 

Franco, O., Steyerberg, E., Hu, F., Mackenbach, J., & Nusselder, W. (2007). Associations of Diabetes Mellitus With Total Life Expectancy and Life Expectancy With and Without Cardiovascular Disease Archives of Internal Medicine, 167 (11), 1145-1151 DOI: 10.1001/archinte.167.11.1145

Knowler, W.C., et al.  Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.  New England Journal of Medicine, 346 (2002): 393-403.

Tuomilehto, J., et al.  Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance.  New England Journal of Medicine, 344 (2001): 1,343-1,350.

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Filed under coronary heart disease, Diabetes Complications, Stroke

Book Review: The Blue Zones

Here’s my review of  The Blue Zones: Lessons for Living Longer From the People Who’ve Lived the Longest, a 2008 book by Dan Buettner.  I give the book four stars on Amazon.com’s five-star system (“I like it”). 

♦   ♦   ♦

The lifestyle principles advocated in The Blue Zones would indeed help the average person in the developed world live a longer and healthier life.  The book is a much-needed antidote to rampant longevity quackery.  Dan Buettner’s idea behind the book was “discovering the world’s best practices in health and longevity and putting them to work in our lives.”  He succeeds. 

Mr. Buettner assembled a multidisciplinary team of advisors and researchers to help him with a very difficult subject.  Do people living to 100, scattered over several continents, share any characteristics?  Do those commonalities lead to health and longevity? 

They studied four longevity hot spots (Blue Zones):

  • Okinawa islands (Japan)
  • Barbagia region of Sardinia (an island off the Italian mainland)
  • Loma Linda, California (a large cluster of Seventh Day Adventists)
  • and the Nicoya Peninsula (Costa Rica). 

Research focused on people who lived to be 100. 

Until recently, two of the Blue Zones—the Nicoyan Peninsula and Sardinia—were quite isolated, with relatively little influence from the outside world. 

Mr. Buettner et al identify nine key traits that are associated with longevity and health in these cultures.  Of course, association is not causation, which Mr. Buettner readily admits.  He draws more conclusions from the data than would many (most?) longevity scientists.  Scientists can wait for more data, but the rest of us have to decide and act based on what we know today.  Here are the “Power Nine”:

  1. regular low-intensity physical activity
  2. hari hachi bu (eat until only 80% full—from Okinawa)
  3. eat more plants and less meat than typical Western cultures
  4. judicious alcohol, favoring dark red wine
  5. have a clear purpose for being alive (a reason to get up in the morning, that makes a difference)
  6. keep stress under control
  7. participate in a spiritual community
  8. make family a priority
  9. be part of a tribe (social support system) that “shares Blue Zone values”

Of these, I would say the available research best supports numbers 1, 4, 7, 8, and the social support system.

I doubt that hari hachi bu (eat until you’re only 80% full) will work for us in the U.S.  It’s never been tested rigorously.  The idea is to avoid obesity.  

The author believes that average lifespan could be increased by a decade via compliance with the Power Nine.  And these would be good, relatively healthy years.  Not an extra 10 years living in a nursing home.

Appropriately and early on, Mr. Buettner addresses the issue of genetics by mentioning a single study of Danish twins that convinces him longevity is only 25% deterimined by genetic heritage.  Environment and lifestyle choices determine the other 75%.  I believe he underestimates the effect of genetics. 

Over half the population of the Nicoya Peninsula Blue Zone are of Chorotega Indian descent, not from Spanish Conquistadores.  Would a Danish twin study have much tosay about Chorotega Indians’ longevity?  We don’t know, but I’m skeptical.  Also, the Sardinians and Okinawans would seem to have centuries of a degree of inbreeding, too, according to Buettner’s own documentation. 
 
Do the Adventists tend to marry and breed with each other (like Mormons), thereby concentrating longevity genes?  You won’t find the question addressed in the book.

Because I think genetics plays a larger role in longevity than 25%, I’d estimate that the healthy lifestyle choices in this book might prolong life by six or seven years instead of 10.  But I’m splitting hairs.  I don’t have any better evidence than Mr. Buettner, just a hunch plus years of experience treating diseased and dying patients.

These four Blue Zones do share a mostly plant-based diet of natural foods with minimal processing.  Two of the populations—the Okinawans and Costa Ricans—didn’t seem to have any choice.  Heavy meat consumption just wasn’t an option available to them.  Rather than promoting a low-meat plant-based diet, it might be more accurate to conclude that “you don’t have to eat a lot of meat, chicken, or fish to live a long healthy life.”

In other words, it may not matter how much meat you eat as long as you eat the healthy optimal level of fruits, vegetables, and whole grains.  It’s a critical difference not addressed in this book except among the Adventists.

Even if you could live an extra two years as a vegan, I’m sure many people would choose to eat meat anyway.  By the way, this book conflates vegan, lacto-vegetarian, lacto-ovo vegetarian, near-vegetarian, and vegetarian into one: vegetarian.  It’s a common problem when considering the health aspects of vegetarianism.  They are not necessarily the same.   

By the same token, plenty of my patients have told me they don’t like any kind of exercise and they won’t do it, even if it would give them an extra two years of life.  What many don’t realize is that from a functional standpoint, regular exercise makes their bodies perform as if they were ten years younger.  There’s a huge difference between the age of 80 and 70 in terms of functional abilities.

Why read the book now that you have the Power Nine?  To convince you to change your unhealthy ways, and indispensible instruction on how to do so.

Steve Parker, M.D.

Disclosure:  The publisher’s representative did not pay me for this review, nor ask for a favorable review.  They offered me a review copy and three give-aways, and I accepted.  I figure the cost of the books to the publisher was $16 USD total.  I gave away the books through my Advanced Mediterranean Diet Blog.  Cost of shipping the books to the winners came out of my pocket.

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