Macular edema is two to five times more common in type 2 diabetics taking pioglitazone or rosiglitazone, according to an article published June 11, 2012, by MedPage Today. The original research was reported in Archives of Internal Medicine.
The macula is the dark area in the middle of the right half of this retina photo
The macula is the most sensitive part of the retina at the back of your eyeball. Edema, or watery swelling, of the macula can impair vision.
Very few patients in the U.S. use rosiglitazone any longer because of concerns about heart toxicity. Pioglitazone has recently been implicated as a cause of bladder cancer.
You can avoid some diabetes drug complications by controlling blood sugars with diet and exercise.
Diabetic Mediterranean Diet 
This is what happens when drugs get approved based upon biomarkers rather than hard end points, be they micro- or macrovascular in the case of diabetes.
Diabetes still has no permanent cure. You can only manage its symptoms and complications.;
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