Macular edema is two to five times more common in type 2 diabetics taking pioglitazone or rosiglitazone, according to an article published June 11, 2012, by MedPage Today. The original research was reported in Archives of Internal Medicine.
The macula is the most sensitive part of the retina at the back of your eyeball. Edema, or watery swelling, of the macula can impair vision.
Very few patients in the U.S. use rosiglitazone any longer because of concerns about heart toxicity. Pioglitazone has recently been implicated as a cause of bladder cancer.
Idris I, et al “Association between thiazolidinedione treatment and risk of macular edema among patients with type 2 diabetes” Arch Intern Med 2012; DOI:10.1001/archinternmed.2012.1938.