Tag Archives: ketogenic mediterranean diet

Hello, World! Announcing the Low-Carb Mediterranean Diet

It’s here.  It’s online.  It’s free.  It’s…

The Low-Carb Mediterranean Diet

Many folks—diabetic or not—following the Ketogenic Mediterranean Diet are interested in expanding their carbohydrate options and consumption.  The Low-Carb Mediterranean Diet (LCMD) does that while aiming to control both excess weight and high blood sugar levels in diabetics, prediabetics, metabolic syndrome.  

Non-diabetics on the KMD can continue with it or move on to the Low-Carb Mediterranean Diet if they wish.  If eating a “diabetic diet” seems weird, just think of the LCMD as a low-carb Mediterranean diet—the world’s first published low-carb Mediterranean Diet, by the way.  How low-carb?  The KMD supplies about 5% of energy (calories) as carbohydrate; the LCMD goes to the 10–20% range.  [By way of reference, most people eat around 55% of caloric intake as carbs.] 

I started this whole project with the goal of helping my personal patients with type 2 diabetes gain the health benefits of the traditional Mediterranean diet: longer lifespan and lower rates of heart attack, stroke, cancer, and dementia, for example.  It’s my sincere hope that it benefits others as well.

Steve Parker, M.D.  

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My Ketogenic Mediterranean Diet and Low-Carb Eating: Six-Month Summary

I started my Ketogenic Mediterranean Diet on September 1, 2009.  After two months, I stopped compulsive record-keeping and food measurement and made a few other intentional tweaks: fish five times a week instead of seven miminum, more nuts (often two ounces a day—I like nuts and they’re convenient), less salad, more dark chocolate.  Otherwise the last four months have been similar to the initial two months of strict KMD.  My daily digestible carbohydrate intake has probably crept up to 40 g compared to 20-25 g on the strict KMD—this is still considered very low-carb. 

Accomplishments

Starting weight was 170 pounds (77.3 kg) on September 1.   After two months—8.6 weeks—my weight clearly stabilized at 155 lb (70.5 kg).  I lost the 15 lb (6.8 kg) over the first six weeks then just hovered around 155 lb.  So average weekly weight loss over the six weeks was 2.5 pounds.  Also lost a couple inches (5 cm) off my waist.

For the last four months—November through February—I’ve been eating the aforementioned liberalized KMD.  Weight has stayed around 155-157 lb (71 kg).  No calorie counting.  I eat as much as I want, except for carbs.  The experience of the first two months taught me how to eat 20-25 g of carbs in a day; it’s the gauge by which I estimate I’m eating 40 g daily now.

Has It Been Easy?

Yeah, relatively easy.  Two other adults in my house are also eating low-carb, which definitely helps.  Blogging here also helps me maintain compliance.  I promised myself to report everything—the good, the bad, and the ugly—honestly.  Accountability is important. 

Staying with the program may be easier for me than for others because I am heavily invested in it, psychologically and time-wise. 

It’s also been helpful for me to participate at two low-carb online communities: LowCarbFriends and Active Low-Carber Forums.  We support each other.  Thanks, guys.

I took diet holidays twice, for three days at both Thanksgiving and Christmas.  Gained three to five pounds (1.8 kg) each time on high-carb eating, but lost it over the next week by returning to the strict KMD.

Any Surprises?

Induction flu.  I’d never heard of it before.  Occurs typically on days 2–5 of very low-carb dieting: achiness and fatigue.  Others also experience headaches and dizziness, and it may last 1–2 weeks.

Rapid weight gain during my diet holidays (aka cheat days).  I was not gorging.  I figure the weight was mostly new glycogen in liver and muscle.  And water.

Eating fish more than once a day is a lot of fish!  Quickly boring, even unappetizing.  But that’s just me.  I need to be a more creative.  Most of my fish lately has been canned tuna.

Assuming that the Daily Values of various nutrients recommended by the U.S. Food and Drug Administration are valid, the KMD foods come up short in many vitamins and minerals.  I bet this is an issue (a problem?) with many, if not most, very low-carb diets if supplements aren’t used.  Those Daily Values are debatable, of course.  For instance, Gary Taubes argues that you don’t need much vitamin C if eating few carbs.  My nocturnal leg cramps and constipation were proof enough for me that I needed at least some supplements.  The recommended KMD supplements remedy the DailyValue shortfall in vitamins and minerals.  Dr. Richard K. Bernstein has a 30-gram carbohydrate diet for his diabetic patients and himself, as outlined in his Diabetes Solution book: no supplements are required.  

As time passes, I worry less about getting enough of various micronutrients.   I feel fine.  I’m still taking the recommended KMD supplements (5 pills a day) plus sugar-free Metamucil.   

I never had hunger that I couldn’t satisfy within the guidelines of the diet. 

No major trouble with cravings or longing for carbs.  I’ve gone six months now without whole grain bread, oatmeal, pizza, and pasta—very unusual for me.  I’d be OK never eating them again.  What I do miss are sweet, often fat-laced, carbohydrates: pie, cookies, cinnamon rolls, candy bars, cake, ice cream.  I doubt that desire will ever disappear, although it does for some who eat very low-carb.   

I counted calories only during the first two months of this experiment.  Remember, fats and proteins are unlimited.  Nevertheless, I ate fewer calories than my baseline intake.   This calorie reduction is a well-documented effect of very low-carb diets.  Fats and proteins are more satiating than carbohydrates.  It’s possible I’ve limited total calories subconsciously. 

[An interesting experiment would be to try to gain weight by over-eating fats and proteins while keeping total digestible carbs under 30 g/day.  Has it been done already?]

What’s Next?

I’d like to answer some intriguing questions.

Why did my weight loss stop where it did, at 155 lb (70.5 kg)? 

If I’d started the KMD at 270 lb (123 kg) instead of 170 lb (77.3 kg), would my weight loss have stopped at 255 lb (116 kg), 210 lb (95.5 kg) or 155 lb (70.5 kg)? 

Will two people, 300 lb each (136 kg), end up at the same final weight when following the program religiously?  Probably not, but why not?    

Six months ago, I believed many scientific studies supported the idea that a higher intake of carbohydrates is healthier, long-term, than the very low-carb Ketogenic Mediterranean Diet and other very low-carb diets.  Studies seemed to support higher carbohydrate intake in the form of traditional fruits, vegetables, legumes, and whole grains.  After reviewing the scientific literature over the last few months, I’m not so sure that higher carb consumption is necessary or beneficial for long-term health and longevity.  The evidence is weak.  Nearly all the pertinent studies are observational or epidemiologic—not the most rigorous science. 

On the other hand, I still can’t help feeling that the recommended eating styles of people like Monica Reinagel, Darya Pino, and Holly Hickman may be healthier than the KMD over the long run, at least for people free of diabetes and prediabetes.  What features unify those three?  Food that is minimally processed, fresh, locally produced when able, including a variety of fruits, vegetables, nuts, whole grains, and legumes. 

It seems that the human body is marvelously designed to survive, even thrive, with multiple ways of eating—but not all ways.   

The strongest evidence for higher carb consumption supports whole grains as a preventative for heart disease (coronary artery disease).  But the effect is modest. 

The argument against higher carb consumption is simple for people with diabetes and prediabetes: carbs raise blood sugar levels, sometimes to an unhealthy degree.  

I don’t see much role for highly processed, refined carbohydrates except as a cheap source of energy (calories).

What’s next for me is to formalize an opinion on which carbs, if any, and in what amount, to add back into the diet of those who have lost weight with the Ketogenic Mediterranean Diet.  The answer will probably be different for two groups:

  1. those who have diabetes, prediabetes, or metabolic syndrome
  2. healthy people who just need to control weight

The goal is to maximize health and longevity without tipping over into excessive carb intake that leads to overweight and obesity with associated illnesses.  

The traditional Mediterranean diet—long associated with health and longevity—is rich in carbohydrates.  The Ketogenic Mediterranean Diet—much lower in carbs—has great potential to help with loss of excess weight and control of blood sugar levels.  Does the KMD incorporate enough of the healthy components of the Mediterranean diet?  We may never know for sure.

Steve Parker, M.D.

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Filed under ketogenic diet, My KMD Experience

What Is Normal Blood Sugar?

Lately I’ve been thinking about which carbohydrates might be added to the Ketogenic Mediterranean Diet to make it healthier yet remain diabetic-friendly.  Carbohydrates—some more than others—tend to elevate blood sugars in diabetics.  If I’m going to recommend adding carbs to the KMD, I have to give some idea what an acceptable blood sugar response would be.  An excessive rise in blood sugar level would necessitate eliminating that carbohydrate, reducing the serving size, or changing the diabetic medication regimen (increase a dose or add a new drug?) 

First off, I’ve reviewed what constitutes blood sugar levels in healthy non-diabetics before and after meals.  Those levels might give us some idea what to shoot for in diabetics. 

The following numbers refer to average blood sugar (glucose) levels in venous plasma, as measured in a lab.  Portable home glucose meters measure sugar in capillary whole blood.  Many, but not all, meters in 2010 are calibrated to compare directly to venous plasma levels.

Fasting blood sugar after a night of sleep and before breakfast: 85 mg/dl (4.72 mmol/l)

One hour after a meal: 110 mg/dl (6.11 mmol/l)

Two hours after a meal: 95 mg/dl (5.28 mmol/l)

Five hours after a meal: 85 (4.72 mmol/l)

(The aforementioned meal derives 50–55% of its energy from carbohydrate)

♦   ♦   ♦

Ranges of blood sugar for young healthy non-diabetic adults:

Fasting blood sugar: 70–90 mg/dl (3.89–5.00 mmol/l)

One hour after a typical meal: 90–125 mg/dl (5.00–6.94 mmol/l)

Two hours after a typical meal: 90–110 mg/dl (5.00–6.11 mmol/l)

Five hours after a typical meal: 70–90 mg/dl (3.89–5.00 mmol/l)

♦   ♦   ♦

Another way to consider normal blood sugar levels is to look at a blood test called hemoglobin A1c, which is an indicator of average blood sugar readings over the prior three months.  The average healthy non-diabetic adult hemoglobin A1c is 5% and translates into an average blood sugar of 100 mg/dl (5.56 mmol/l).  This will vary a bit from lab to lab.  Most healthy non-diabetics would be under 5.7%.

What Level of Blood Sugar Defines Diabetes and Prediabetes?  

According to the 2007 guidelines issued by the American Association of Clinical Endocrinologists:

Prediabetes (or impaired fasting glucose): fasting blood sugar 100–125 mg/dl (5.56–6.94 mmol/l)

Prediabetes (or impaired glucose tolerance): blood sugar 140–199 mg/dl (7.78–11.06 mmol/l) two hours after ingesting 75 grams of glucose

Diabetes: blood sugar 200 mg/dl (11.11 mmol/l) or greater two hours after ingesting 75 grams of glucose

Diabetes: random blood sugar 200 mg/dl (11.11 mmol/l) or greater, plus symptoms of diabetes

For my current thoughts on blood sugar goals for diabetics and prediabetics, please see the bottom half  of my “What is Normal Blood Sugar” page.

Steve Parker, M.D.

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Does Diet Influence Risk of Stroke?

Harvard researchers suggest that our food consumption does indeed influence our risk of suffering a stroke.  This matters since stroke is the third leading cause of death in the U.S.

Scientists looked carefully at 121 different studies—published between 1979 and 2004—on the relationship between dietary factors and stroke.  High blood pressure is a major modifiable risk factor for stroke, so it also was considered.  Dietary factors included fats, minerals, animal protein, cholesterol, fish, whole grains, fiber, carbohydrate quality, fruits and vegetables, antioxidants, B vitamins, and dietary patterns.

I quote their conclusions:

Diets low in sodium and high in potassium lower blood pressure which will likely reduce stroke risk.

Consumption of fruits and vegetables, whole grains, folate, and fatty fish are each likely to reduce stroke risk.

A prudent or traditional Mediterranean dietary pattern, which incorporates these individual dietary components as well as intake of legumes and olive oil, may also prevent stroke.

Evidence is limited or inconsistent regarding optimal levels of dietary magnesium, calcium, antioxidants, total fat, other fat subtypes, cholesterol, carbohydrate quality, or animal protein for stroke prevention.

A diet low in sodium, high in potassium, and rich in fruits, vegetables, whole grains, cereal fiber, and fatty fish will likely reduce the incidence of stroke.

Take Home Points

The article abstract does not address the optimal intake amount of these various foods, vitamins, and minerals.  That’s probably not known with any certainty.

The traditional Mediterranean diet incorporates many of these stroke-preventing foods.  The Advanced Mediterranean Diet helps people lose weight while teaching how to eat Mediterranean-style.

The very low-carb Ketogenic Mediterranean Diet includes these stroke-preventing foods and minerals, except for whole grains and a tendency to be low in potassium.  The KMD is high in total fat and animal protien, and potentially high in cholesterol; this study indicates those issues are nothing to worry about in terms of future strokes.

I’ll use articles such as this to recommend long-term food consumption for followers of any future Diabetic Mediterranean Diet.

Steve Parker, M.D.

Reference:  Ding, E.L, and Mozaffarian, D.  Optimal dietary habits for the prevention of stroke. Seminars in Neurology, 26 (2006): 11-23.

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Filed under Fish, Fruits, Grains, Health Benefits, legumes, Mediterranean Diet, olive oil, Stroke, Vegetables

Walnuts: More Evidence in Favor of Health Benefits

MPj03095770000[1]Nuts are a time-honored component of the Mediterranean diet and may contribute to the lower risk of cardiovascular disease  associated with the diet. 

Regular nut consumption lowers total cholesterol and LDL (“bad cholesterol”) by 5 to 15%, which would tend to lower heart disease risk.  Walnuts are particularly high in alpha-linolenic acid, an omega-3 fatty acid.

Bix over at Fanatic Cook links to three scientific studies showing that walnuts:

  • improved arterial function in people with type 2 diabetes
  • improved arterial function in people with high cholesterol eating a Mediterranean diet
  • decreased fasting insulin levels in people with type 2 diabetes
  • decreased LDL cholesterol in people with type 2 diabetes who were on a low-fat diet

The “dose” of walnuts in these studies was 1–2 ounces (28–56 g) daily.

For good reason, nuts have a prominent role in both the Advanced Mediterranean Diet and Ketogenic Mediterranean Diet

I don’t know Bix, but he or she seems to base many of his/her nutrition opinions on scientific principles, which I appreciate.

Steve Parker, M.D.

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Filed under coronary heart disease, Mediterranean Diet, nuts, Shameless Self-Promotion

Nuts: The Healthy Snack

MPj04031620000[1]Nut consumption is strongly linked to reduced coronary heart disease, with less rigorous evidence for several other health benefits, according to a recent article in the American Journal of Clinical Nutrition.

This is why I’ve included nuts as integral components of the Ketogenic Mediterranean Diet and the Advanced Mediterranean Diet.

Regular nut consumption is associated with health benefits in observational studies of various populations, within which are people eating few nuts and others eating nuts frequently.  Health outcomes of the two groups are compared over time.  Frequent and long-term nut consumption is linked to:

  • reduced coronary heart disease (heart attacks, for example)
  • reduced risk of diabetes in women (in men, who knows?)
  • less gallstone disease in both sexes
  • lower body weight and lower risk of obesity and weight gain 

The heart-protective dose of nuts is three to five 1-ounce servings a week.

Steve Parker, M.D.

Reference:  Sabaté, Joan and Ang, Yen.  Nuts and health outcomes: New epidemiologic evidenceAmerican Journal of Clinical Nutrition, 89 (2009): 1,643S-1,648S.

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Filed under Health Benefits, Mediterranean Diet, Prevention of T2 Diabetes

My Ketogenic Mediterranean Diet: Day 2

NOT on KMD

NOT on KMD

Weight: 170 lb (same as starting weight)

Transgressions: none

Exercise: none

Comments

Woke up thirsty in the middle of the night, got a cup of water.  Thought this might reflect the “water loss” associated (at least in the literature) with very low-carb diets.  The metabolism/breakdown of glycogen—a storage form of glucose in the liver and muscles (aka animal starch)—is said to generate water that will either have to be urinated out or lost through breathing (water vapor) or sweating.  But my weight didn’t change.  Thirst may have been due to 20% humidity in the Sonoran desert, although I don’t usually wake up for water.

I was a little tempted by a fruit platter in the doctor’s lounge at the hospital: fresh pineapple, cantaloup, honeydew melon, and strawberries.

Steak and eggs for breakfast last two days.  Wonder when that will get old.  Enjoying for now.

-Steve

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My Ketogenic Mediterranean Diet: Day 1

 

Very low-carb chicken

Very low-carb chicken

Today I’m starting a very low-carb diet, the Ketogenic Mediterranean Diet, to lose only about 10 lb (4.55 kg) of fat I’ve accumulated around my waist over the last six months. 

 

I gained the weight intentionally, so I’d have something to experiment on.  Cookies, candy bars, ice cream, cinnamon rolls and other pastries, pies, cakes, fried pies, french fries, shakes and malts—all these reliably put extra weight on me.  It’s not been a burden to gain the weight.  I did it for Science!

My current stats

Weight: 170 lb (77.3 kg)

Height: 71 inches (180 cm)

Body mass index: 23.8

Waist circumference: 36.5 inches (92.7 cm)

Usual  caloric intake: 2400/day (from prior self-experimentation and food diaries)

Activity level:  somewhat active

Health status:  Good.  No trouble with high cholesterol or trigylcerides, diabetes, heart disease, high blood pressure.

Comments

My body mass index is in the healthy range, so the 10 pounds I want to lose are “vanity pounds.”  You wouldn’t call me fat.  Maybe “a little chubby.”  My daughter and mother both spontaneously mentioned the excess weight to me.  My usual adult weight is around 160 pounds.  I dropped to 148 once through caloric restriction; my wife thought that was too low. 

My Plans

I’ll report here daily regarding weight, dietary transgressions, exercise, random thoughts, etc.  If it’s not too much hassle, I’ll track my food intake at NutritionData.com and share the nutritional analysis weekly.  I’m hoping I don’t get too busy to keep this up.

Steve Parker, M.D.

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Spanish Ketogenic Mediterranean Diet

Altea, Plaça de la EsglésiaEver heard of the Spanish Ketogenic Mediterranean Diet?  It looks like a low-carb quasi-Mediterranean diet.

Researchers with the University of Cordoba in Spain studied 40 subjects eating a low-carb “Mediterranean” diet for 12 weeks.  The results were strikingly positive.

Methodology

A medical weight loss clinic was the source of 40 overweight subjects, 22 males and 19 females, average age 38, average body mass index 36.5, average weight 108.6 kg (239 lb).  These folks were interested in losing weight, and were not paid to participate.

Nine subjects were not included in the final analysis due to poor compliance with the study protocol (3), the diet was too expensive (1), a traumatic car wreck (1), or were simply lost to follow-up (4).  So all the data are pooled from the 31 subjects who completed the study.

Blood from all subjects was drawn just before the study began and again after 12 weeks of the diet.

Study diet:  Low-carbohydrate, high in protein [and probably fat, too], unlimited in calories.  Olive oil was the main source of fat (at least 30 ml daily).  Maximum of 30 grams of carbohydrates daily as green vegetables and salad.  200-400 ml daily of red wine.  The authors write:

Participants were permitted 3 portions (200 g/portion) of vegetables daily: 2 portions of salad vegetables (such as alfalfa sprouts, lettuce, escarole, endive, mushrooms, radicchio, radishes, parsley, peppers, chicory, spinach, cucumber, chard and celery), and 1 portion of low-carbohydrate vegetables (such as broccoli, cauliflower, cabbage, artichoke, eggplant, squash, tomato and onion).  3 portions of salad vegetables were allowed only if the portion of low-carbohydrate vegetables were not consumed.  Salad dressing allowed were: garlic, olive oil, vinegar, lemon juice, salt, herbs and spices.

The minimum 30 ml of olive oil were distributed unless in 10 ml per principal meal (breakfast, lunch and dinner).  Red wine (200–400 ml a day) was distributed in 100–200 ml per lunch and dinner.  The protein block was divided in “fish block” and “no fish block”.  The “fish block” included all the types of fish except larger, longer-living predators (swordfish and shark).  The “no fish block” included meat, fowl, eggs, shellfish and cheese.  Both protein blocks were not mixed in the same day and were consumed individually during its day on the condition that at least 4 days of the week were for the “fish block”.

Trans fats (margarines and their derivatives) and processed meats with added sugar were not allowed.

Vitamin and mineral supplements were given.

Subjects measured their ketosis state every morning with urine ketone strips.

Results (averaged)

  • Body weight fell from 108.6 kg (239 lb) to 94.5 kg (209 lb), or 2.5 pounds per week
  • Body mass index fell from 36.5 to 31.8
  • Systolic blood pressure fell from126 to 109 mmHg
  • Diastolic blood pressure fell from 85 to 75 mmHg
  • Total cholesterol fell from 208 to 187 mg/dl
  • LDL chol fell from 115 to 106 mg/dl
  • HDL chol rose from 50 to 55 mg/dl
  • Fasting glucose dropped from 110 to 93 mg/dl
  • Triglycerides fell from 219 to 114 mg/dl
  • No significant differences in male and female subjects
  • No adverse reactions are mentioned

Researchers’ Conclusions

The SKMD [Spanish Ketogenic Mediterranean Diet] is safe, an effective way of losing weight, promoting non-atherogenic lipid profiles, lowering blood pressure and improving fasting blood glucose levels.  Future research should include a larger sample size, a longer term use and a comparison with other ketogenic diets.

My Comments

The researchers called this diet “Mediterranean” based on olive oil, red wine, fish, and vegetables.

What’s “Not Mediterranean” is the paucity of carbohydrates (including whole grains); lack of yogurt, nuts, and legumes; and the high meat/protein intake.

The emphasis on olive oil, red wine, and fish could make this healthier than other ketogenic diets.

Ketogenic diets are notorious for high drop-out rates compared to other diets.  Most people can follow a ketogenic diet for only two or three months.  But several studies suggest greater short-term weight loss for people who stick with it.  Efficacy and superiority are little different from other diets as measured at one year out.

Many of the metabolic improvements seen here might be duplicated with loss of 30 pounds (13.6 kg) over 12 weeks using any reasonable diet.

Average fasting blood sugars in these subjects was 109 mg/dl.  Although not mentioned by the authors, this is in the prediabetes range.  The diet reduced average fasting blood sugar to 93, which would mean resolution of prediabetes.  Dropping body mass index from 36 to 32 by any method would tend to cure prediabetes.

Elevated blood sugar is one component of the “metabolic syndrome.”  Metabolic syndrome was recently shown to be reversible with a Mediterranean diet supplemented with nuts.

I suspect this would be a good program for an overweight person with uncontrolled type 2 diabetes, too.  But it has never been studied in a diabetic population.  So, who knows for sure?

If you’re thinking about doing something like this, get more information and be sure to get your doctor’s approval first.

Steve Parker, M.D.

Addendum:

On April 6, 2008, I had a delightful conversation with Jimmy Moore, of Livin’ La Vida Low-Carb fame regarding this study.  It struck me that the Spanish Ketogenic Mediterranean Diet is probably higher in protein and lower in fat than many other ketogenic weight-loss diets.  Since fish is emphasized over other animal-derived foods, it’s likely also lower in saturated fat.  [In low-carb diets, carbohydrates are substituted with either fats or proteins.]  I’m also convinced I will eventually have to review the validity of the dogmatic diet-heart hypothesis:  Dietary saturated fat, total fat, and cholesterol contribute to atherosclerosis and associated premature death from heart attacks and strokes.

References and Additional Reading:

Perez-Guisado, J., Munoz-Serrano, A., and Alonso-Moraga, A.  Spanish Ketogenic Mediterranean diet: a healthy cardiovascular diet for weight lossNutrition Journal, 2008, 7:30.   doi:10.1186/1475-2891-7-30

Bravata, D.M., et al.  Efficacy and safety of low-carbohydrate diets: a systematic reviewJournal of the American Medical Association, 289 (2003): 1,837-1,850.

Gardner, C.D., et al.  Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trialJournal of the American Medical Association, 297 (2007): 696-677.

Stern, L., et al.  The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trialAnnals of Internal Medicine, 140 (2004): 778-785.

Shai, Iris, et al.  Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat DietNew England Journal of Medicine, 359 (2008): 229-241.

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Filed under Carbohydrate, ketogenic diet, Weight Loss