Tag Archives: ancel keys

Denise Minger on the Purported Cherry-Picker Ancel Keys

Keys lived his last years in Pioppi, Italy, not near the Tower of Pisa

Here’s her take on Ancel Keys, the father of cardiovascular epidemiology and the what we now consider the healthy Mediterranean diet. She is funny. Warning: Her post is only for serious nutrition science geeks.

Too bad he’s not alive to defend himself. He died young, almost reaching 101.  Check out his New York Times obituary.

Steve Parker, M.D.

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Origins and Definition of the Mediterranean Diet


It all starts with Ancel  Keys.

Keys was the leader of the team who put together the Seven Countries Study, which seemed to demonstrate lower rates of coronary heart disease in countries consuming less saturated fat.  [Coronary heart disease is the leading cause of death in Western cultures.]  He also found that cardiovascular disease rates rose in tandem with blood cholesterol  levels.  The two countries particularly illustrative of these connections were Italy and Greece, both Mediterranean countries.

The other countries he analyzed in Seven Countries were the United States, Yugoslavia, Japan, Finland, and the Netherlands.

Keys and his wife Margaret, a biochemist, drilled deeper in to the “Mediterranean diet” that was characteristic of Italy, Greece, and other countries on or near the Mediterranean Sea in the 1950s and 1960s.  [“Diet” in this context refers to the usual  food and drink of a person, not a weight-loss program.]  Their efforts culminated in the publication of several best-selling Mediterranean diet books in the 1970s, and Keys’ photo on the cover of Time magazine in 1961.

Thus began the still-popular healthy Mediterranean diet.

Oldways Preservation Trust re-invigorated the Mediterranean diet around 1990, helping the public incorporate Mediterranean diet principals into everyday life.  Oldways founder, K. Dun Gifford, passed away within the last year.


There is no monolithic, immutable, traditional Mediterranean diet.  But there are similarities among many of the regional countries that tend to unite them, gastronomically speaking.  Greece and southern Italy are particularly influential in this context.

So here are the characteristics of the traditional Mediterranean diet  of the mid-20th century:

•It maximizes natural whole foods and minimizes highly processed ones

•Small amounts of red meat

•Less than four eggs per week

•Low to moderate amounts of poultry and fish

•Daily fresh fruit

•Seasonal locally grown foods with minimal processing

•Concentrated sugars only a few times per week

•Wine in low to moderate amounts, and usually taken at mealtimes

•Milk products (mainly cheese and yogurt) in low to moderate amounts

•Olive oil as the predominant fat

•Abundance of foods from plants: vegetables, fruits, beans, potatoes, nuts, seeds, breads and other whole grain products

•Naturally low in saturated fat, trans fats, and cholesterol

•Naturally high in fiber, phytonutrients, vitamins (e.g., folate), antioxidants, and minerals (especially when compared with concentrated, refined starches and sugars in a modern Western diet)

•Naturally high in monounsaturated and polyunsaturated fats, particularly as a replacement for saturated fats


Keys has been criticized for “cherry-picking” the data that linked saturated fat consumption with increased heart disease.  In other words, the allegation is that he used information if it supported his theory, while ignoring data that was contrary or neutral.  Subsequent studies indicate a weak link, if any, between saturated fat consumption and heart disease.  A list of the pertinent studies de-linking heart disease and saturated fat is at my Advanced Mediterranean Diet Blog.

The Seven Countries Study included only men.  It’s practical implications, therefore, may not apply to women.

The traditional Mediterranean diet is increasingly a thing of the past as Mediterranean countries adopt the Western diet characterized by “fast food” and highly processed foods.


Ever heard of K rations used by the U.S. military in World War II?  Keys invented them.  He earned Ph.D.s in biology and physiology.  Keys lived to age 100 and was said to be intellectually active through his 97th year.

Steve Parker, M.D.

PS:  The Mediterranean diet has too many carbohydrates (55% of total energy) for for most people with diabetes.  Hence, the Low-Carb Mediterranean Diet.


Keys, Ancel.  Coronary heart disease in seven countries.  Circulation, 41, (1970) supplement I: I-1 through I-211.

Keys, Ancel.  Seven Countries:  A Multivariate Analysis of Death and Coronary Artery Disease.  Harvard University Press, 1980.

Oldways website.


Filed under Mediterranean Diet