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Book Review: Sugar Nation – The Hidden Truth Behind America’s Deadliest Habit and the Simple Way to Beat It

I recently read Sugar Nation, by Jeff O’Connell, published in 2011.  Per Amazon.com’s rating system, I give it five stars (“I love it”). 

♦   ♦   ♦

With the U.S. Centers for Disease Control predicting that one of every three citizens born in 2000 will become diabetic, this book is “just what the doctor ordered.”  Already,  one in three of all adults has prediabetes.  The numbers are even scarier if we look at those over 65: HALF have prediabetes, while two in ten have diabetes.  I treat diabetes every day; trust me, you don’t want it.

I agree with O’Connell that over-consumption of sugar and refined starches often leads to type 2 diabetes and prediabetes, particularly when combined with obesity, a sedentary lifestlye, and genetic predisposition.  (Our bodies easily and quickly convert potatoes and refined starches like white flour and white rice into blood sugar.) Yearly sugar consumption in the U.S. was five pounds per person in the 1800s, but is now up to 160 pounds a year. 

O’Connell was motivated to write this because of his personal diagonosis of prediabetes in 2006.  Later he was also diagnosed with reactive hypoglycemia.  Furthermore, his father died of the ravages of type 2 diabetes.  O’Connell’s physician in 2006 didn’t offer much managmement advice, so the author did his own research and shares it with us here.  The author’s personal approach has been a fairly intense exercise program and major reduction in consumption of sugar and other carbohydrates, particularly ones that are quickly converted to blood sugar.  He eats 80 or less grams of carb daily, compared to the average American’s 275 grams.  I agree these management options can be extremely helpful for prediabetes and type 2 diabetes, particularly if applied early in the course of the condition.

O’Connell is critical of most physicians and the American Diabetes Association (ADA) for not knowing about carbohydrate restriction and for inadequately promoting exercise.  He accuses the pharmaceutical industry of having too much influence over physicians and the ADA.  While admitting that “…taking a pill [is] much easier than reengineering the way you lead your life,” he mostly lets patients off the hook in terms of taking control of diet and physical activity.  I can understand that to a degree; physicians should be leading the way.  I don’t see that happening soon.  Patients need to take charge now; many have already done so.  Compared to a five-minute lecture in a doctor’s office, this book will be a much more effective motivator for change.

(Patients taking drugs with the potential to cause hypoglycemia need their doctors’ help adjusting dosages while making these lifestyle changes.)

The author tells us that we in the U.S. spent $12.5 billion on drugs for diabetes in 2007, nearly double the amount spent in 2001.  It’s only going to get worse going forward.  We have 11 classes of drugs for diabetes now.  Surprisingly, we don’t know all of the potential adverse long-term side effects of most of these drugs.  Phenformin was pulled from the U.S. market years ago due to fatal lactic acid build-up.  Earlier this year, rosiglitazone prescribing was greatly restricted in view of adverse heart effects.  If we can effectively address diabetes and prediabetes with diet and exercise, why not?  (Clearly, diet and exercise don’t always work, and type 1 diabetics always need insulin.) 

For those who won’t or can’t exercise regularly, be aware that carb restriction alone is a powerful approach.

I heard more about reactive hypoglycemia a couple decades ago than I do now.  It could be a precursor to type 2 diabetes.  I think physicians lost interest in it because too many people were using it as a excuse for odd behavior when they really didn’t have hypogylcemia.  This book may spark a resurgence in interest.

O’Connell implies that the high revenues generated by diabetic drug manufacturers may not be justifiable.  In fairness, I must point out that the same companies spend hundreds of millions of dollars just to get a drug on the market, and millions more on research for drugs that fail and never see the light of day.

I was glad to see the author mention low-carb beers: Michelob Ultra and MGD 64.  I’ve had trouble finding carb counts on many beers.

O’Connell recommends supplements: leucine, cinnamon, protein powder, chromium, alpha lipoic acid, biotin, magnesium.  I’ve not done in-depth research on most of those.  What I’ve read in the science literature about cinnamon and chromium has not been very positive or definitive.

My favorite sentence: “Along with a low-carb eating plan, a gym memership is the most potent antidote to type 2 diabetes.”  Nevertheless, don’t let this turn you off; you can do the essential exercise without a gym membership.

This book was a pleasure to read; professional, well-organized, touching all the right bases in understandable terms.  I can well understand how he makes a living as a journalist. 

Steve Parker, M.D., author of Conquer Diabetes and Prediabetes: The Low-Carb  Mediterranean Diet   

Disclosure: I don’t know the author.  The publisher’s representative provided me with two free copies of the book, otherwise I recieved nothing of value in exchange for this review.  I gave one of the books to a contest-winner at my Advanced Mediterranean Diet blog.  The contest was to be the first reader to e-mail me with the name for “wisps of precipitation streaming from a cloud but evaporating before reaching the ground.”

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What About Triglycerides?

 

Great source of marine omega-3 fatty acids

Circulation recently published the American Heart Association Scientific Statement: Triglycerides and Cardiovascular Disease.  I’ve not read the full document, but here are a few tidbits I’ll share:

  • Triglycerides (TGs) are not direclty atherogenic; they are a biomarker for cardiovascular risk
  • Optimal fasting TGs are under 100 mg/dl (1.1 mmol/l)
  • Normal nonfasting TGs are under 200 mg/dl (2.3 mmol/l)
  • If levels are high, treatment focuses on intensive therapeutic lifestyle change
  • To reduce high TGs, diet modifications include reduction of “simple carbohydrates” like added sugars and fructose by replacing with unsaturated fats, implementing a Mediterranean-style diet, reduction of saturated fat and trans fat consumption, increased marine omega-3 fatty acid intake
  • To reduce high TGs in the setting of overweight and obesity, aim for loss of 5 or 10% of body weight
  • To reduce high TGs, do aerobic exercise at least twice weekly

From my quick scan, I didn’t see much effort to push drugs on people with triglycerides under 500 mg/dl (5.6 mmol/l).

Thanks to Circulation for making this available to the public at no charge.

Steve Parker, M.D.

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Research Round-Up

 

I have a stack of scientific articles I’ve been meaning to review in depth and blog about.  But I have to finally admit I don’t have the time.  Here they are.  Click through for details.

  1. Long-term calorie restriction in humans appears highly effective in reducing atherosclerosis risk factors (lab tests) and actual carotid artery atherosclerosis. Only 18 study subjects, however.
  2. A very-low-carbohydrate diet improved memory in older adults with mild cognitive impairment over six weeks.  Twenty-three subjects were randomized to either high-carb or very-low-carbohydrate diet.  The low-carbers improved verbal memory performance, lost weight, reduced fasting blood sugar and fasting insulin levels.  Ketone levels were positively correlated with memory performance.
  3. A high-fat diet impairs cognitive function and heart energy metabolism in young men.  Sixteen test subjects.  Crossover study design with a five-day high-fat diet deriving 75% of energy from fat, compared to a low-fat diet deriving 23% of energy from fat.  High-fat diet led to impaired attention, speed, and mood.  I’m sure low-carb bloggers have been all over this.  At first blush, it appears they were testing during “induction flu” phase of very-low-carb eating, between days 2 to 7 of a new ketogenic diet.  It takes several weeks to adapt metabolism to running almost entirely on fat rather than standard carbohydrates.  Suspect results would have been different if given time to adapt.
  4. Weight-loss with the laparoscopic gastric banding procedure has poor long-term outcome, according to Belgian surgeons reporting on 82 patients.  Four in 10 patients had major complications.  Nearly half of the 82 patients needed to have the bands removed, and six of every 10 required some kind of re-operation.
  5. Trust me, you DON’T want age-related macular degeneration.  Women, reduce your risk of ARMD with a healthy lifestyle, including regular exercise, avoidance of smoking,  and by eating abundant plant foods (vegetables [including orange and dark leafy green ones], fruits, and whole grains) and limit foods high in fat, refined starches, sugar, alcohol, and oils.  At least according to these researchers. 
  6. Leafy green vegetables and olive oil are linked to reduced heart disease (CHD) in Italian women.  Fruit consumption had no effect.  This is from a subset of the huge EPIC study, following 30,000 women over almost eight years.
  7. The Mediterranean diet protects against metabolic syndrome, reducing risk by about a third according to a huge meta-analysis from Greek and Italian investigators.  It works best in Mediterranean countries. 
  8. The Mediterranean diet was linked to slower rates of cognitive decline in Chicago residents over the course of almost eight years.  The comparison diet was the Healthy Eating Index-2005.  Of the 3,800 participants, about two-thirds were black.  A Manhattan population showed lower risk of dementia when eating Mediterranean-style.

There ya’ go.  This is better than letting the articles just sit in my briefcase for months on end, eventually to be thrown out.

Steve Parker, M.D.

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Egyptian Mummies with Atherosclerosis in the News Again

Remember about a year ago the report that hardening-of-the-arteries was found in Egyptian mummies?  The heart arteries were  also involved.  Princess Ahmose-Meryet-Amon is officially the first person in history diagnosed with coronary heart disease. 

This finding is noteworthy in view of the common view that atherosclerosis is a disease of modern civilization (usually referring to the last one or two hundred years).

You’ll find more details at this May 17 post at CardioBrief. 

We’ll know more if these researchers ever publish their findings in a peer-reviewed scientific journal.

Steve Parker, M.D.

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Diabetic Drug Pioglitazone Linked to Bladder Cancer

A recent report in Diabetes Care (doi 10.2337/dc10-2412) suggests a link between pioglitzone and the development of bladder cancer.  This is preliminary, not definitive proof.  Further study may erase all concern about bladder cancer.  The only other diabetic drug in this class (thiazolidinediones) is rosiglitazone: its use was just recently drastically reduced by the Food and Drug Administration.

Will pioglitazone eventually be pulled from the market because of this?  How many will suffer from bladder cancer in the meantime?  Nobody knows at this point.

We have 11 classes of drugs to treat diabetes.  Would you believe we don’t know all the potential long-term adverse effects of most of these drugs?  It’s true.

To me, that’s more reason to control diabetes with diet modification, such as the Low-Carb Mediterranean Diet or Dr. Bernstein’s Diabetes Solution.

Steve Parker, M.D.

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Mediterranean Diet Linked to Fewer Strokes on MRI Scans

The Mediterranean diet reduces the risk of strokes seen on brain MRI scans, according to a study earlier this year in Annals of Neurology. 

Brain researchers at various U.S. institutions studied a multi-ethnic population in upper Manhattan (the WHICAP cohort).  Average age of the  707 study participants was 80.  Baseline diet was determined by a questionairre.  A Mediterranean diet score was calculated to quantify adherence—or lack thereof—to the Mediterranean diet.  Participants without dementia at baseline underwent MRI scanning initially, then again an average of six years later.

What Did They Find?

One third of participants had MRI evidence for a stroke.  Higher adherence to the Mediterranean diet was linked to significantly lower odds of stroke.  Compared to those eating least like the Mediterranean diet, those with the highest adherence had 37% lower odds of an stroke being found on MRI scan.  Those with medium adherence had 20% lower odds.

So What?

This is the first study to show such an association between strokes on an MRI scan and the Mediterranean diet.  Be aware that you can find stroke on an MRI scan in someone who thought they were perfectly healthy; in other words a clinically silent stroke.  The authors note only one previous report finding lower risk of clinically obvious stroke with the Mediterranean diet, in women—I thought there were more. 

The same group of researchers had previously demonstrated that higher compliance with the Mediterranean diet is linked to lower risk of Alzheimers disease and mild cognitive impairment. 

If I wanted to protect my brain from stroke, I’d be sure follow a Mediterranean-style diet, keep my blood pressure under 140/90 mmHg, stay physically active, keep my weight under control, and not smoke. 

Steve Parker, M.D.

 
Reference:  Scarmeas, Nikolaos, et al.  Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular disease.  Annals of Neurology, 69 (2011): 257-268.  doi: 10.1002/ana.22317

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Two-Minute Online Diabetes and Prediabetes Risk Test

In the U.S., 24 million people have diabetes, mostly type 2.  That’s one in 10 adults.  The number for those over 60 is two in 10. 

Fifty-seven million have prediabetes; that’s one of every three adults.  Most of them are unaware of it.

The American Diabetes Association offers an online diabetes and prediabetes risk assesment.  The Centers for Disease Control says one of every three people born in 2000 will develop diabetes.   A few risk factors are age over 45, family history of diabetes, sedentary lifestyle, and overweight or obese.  Why not recommend the test to someone you know who may be at risk? 

Steve Parker, M.D., author of Conquer Diabetes and Prediabetes: The Low-Carb Mediterranean Diet

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Eat Natural Food

Michael Pollan is credited with the aphorism, “Eat food.  Not too much.  Mostly plants.”

Bill Gottlieb interviewed me recently on the topic of prediabetes for a book due out later this year (Bottom Line’s Breakthroughs in Natural Healing 2012).  Bill had given me a preparatory list of potential questions, one of which was,”What are the best dietary recommendations? I’m looking for fun, fresh specificity here—along the lines of your book!”  Also, “What’s the best way for a person to implement it—specific, practical, small-step actions that would lead to actually changing the diet?”

We didn’t have a chance to get to those in the interview, but here are some of my thoughts:

  • Give up all man-made food*
  • Give up all sugar-sweetened sodas and “sports drinks”
  • Give up all flour products
  • Give up all flours, starches, and added sugars
  • Give up deserts

But “giving up” is not a message  people want to hear when contemplating a diet change, even if it’s for their own good.  “Avoid” and “cut back on” are not specific.  “Forego” works, but is just a euphemism for “give up.”  “Eat only God-made foods” might turn off the atheists and agnostics.

Here’s a more marketable catch-phrase that I rather like:

Eat natural food.*

By “natural,” I mean “present in or produced by nature.”  This would not include candy bars, potato and corn chips, soda pop, sports drinks, apple pie, bread and other flour products, cookies, etc.  That still leaves a lot of different foods to eat, including most  of the items on the Low-Carb Mediterranean Diet.  Whether modern, mass-produced versions of fruits and vegetables are natural is a debate for another day.  I suspect modern corn, for example, is nothing close to the maize cultivated by Native Americans 400  years ago. 

Why the asterisk?  The exceptions to the “eat natural food” rule are red wine, olive oil, and vinegar.  Those are partly natural, partly man-made.  (Where do we get vinegar?)  The red wine and olive oil are potentially healthful, and many of us like vinegar on our  natural salad vegetables.

Eat natural food.

I bet the average person eating the standard American diet would tend to lose excess weight and be healthier by making the switch.

Steve Parker, M.D.

* Exceptions: red wine, olive oil, vinegar

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Carbohydrates Can Kill

Carbohydrates Can KillI did a phone interview yesterday with Dr. Robert K. Su, author of Carbohydrates Can Kill.  It should be available in podcast form at Dr. Su’s website within the next three months.  Dr. Su is on a mission to educate the public on the dangers of excessive blood sugar levels, whether or not diabetes or prediabetes is present.  Visit Dr. Su’s website for a wealth of information on carbohydrates and their effects on blood sugar levels and health.

Steve Parker, M.D., author of Conquer Diabetes and Prediabetes: The Low-Carb Mediterranean Diet

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Greater Risk of Death in Diabetics with Lower Salt Intake

Have you noticed the national push for lower salt consumption? It’s driven by the idea that lower consumption will reduce the risk of heart attacks, strokes, and death, supposedly mediated through lower blood pressure.

The latest issue of Diabetes Care has a research report showing a greater risk of death in type 2 diabetics with lower salt consumption over the course of 10 years. Yes, you read that right: greater risk of death with lower salt consumption.

Keep your eyes and ears open on this issue.

Steve Parker, M.D.

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