Sulfonylurea Diabetes Drugs Linked to Heart Disease in Women

…according to this article at Diabetes Care. The study population was the Nurses Health Study. The longer the sulfonylurea was used, the stronger the association with coronary heart disease. CHD is by far the most common cause of heart attacks. On the bright side, the drugs were not linked to stroke risk. Remember, correlation is not causation, blah, blah, blah…

I rarely start my patients on sulfonylureas these days.

Steve Parker, M.D.


Filed under Drugs for Diabetes, Heart Disease

3 responses to “Sulfonylurea Diabetes Drugs Linked to Heart Disease in Women

  1. This is slightly unrelated, but why would someone with Type II on a low carb diet 50-90g/day from beans, sweet potatoes, veggies, berries, (occasional thin slice of homemade bread) continue to experience increased blood sugar and A1C? Not drastic, but after overhauling their diet for 1 year A1C has increased from 7.4 to 7.9.

    • Hi, Brenna. In that case, I’d think about drugs that might aggravate diabetes (e.g., corticosteroids), lack of exercise, excess body weight (insulin resistance), dietary indiscretions, hidden dietary carbohydrates (e.g., condiments they’re not counting), and simple unavoidable progression of the underlying diabetes.

      • I was questioning if his pancreas was slowly making less insulin. He is not overweight, and is a carpenter, so his job is very physical. I’m having him check his blood sugars 2 hr. after meals, instead of fasting (per his MD) to help him see how foods affect him.