Metformin: New Uses for an Old Drug

Metformin? A shirt from 1967?

Medical Xpress has an article about the possible future uses of metformin for weight loss, prostate cancer treatment, and tuberculosis treatment. It didn’t mention metformin as an anti-aging drug.

From the article:

Among medications, metformin has a long and storied past. The compound destined to become metformin was first isolated during the Middle Ages from the French lilac, a plant scientifically known as Galega officinalis. Ground flowers and leaves were administered by healers to patients suffering from constant urination, a hallmark of a disorder that later would become known as diabetes. The active ingredient in French lilac, a plant also called goat’s rue, was identified hundreds of years later as galegine, which triggered a striking reduction in blood glucose.

By the 1950s, scientists were able to exploit folk medicine uses and develop the drug that became metformin.

Source: Wonder drug? Exploring the molecular mechanisms of metformin, a diabetes drug with Medieval roots

Don’t believe everything you read. The article claims metformin’s effectiveness in type 2 diabetes is primarily due to weight loss. Conventional thinking is that it’s mostly due to decreased production and release of glucose by the liver. I guess time will tell which theory wins out. In either case, it’s a good initial drug for T2 diabetes if diet and exercise prove inadequate.

Steve Parker, M.D.

low-carb mediterranean diet

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Prepare Your Household for Coronavirus

Advanced civilizational collapse

I hadn’t been too concerned about coronavirus (COVID-19), but then I read about quarantined towns in northern Italy. I’m still not terribly worried for my own health, even if I end up treating cases at the hospital. I’m 65—a risk factor for viral death—but otherwise healthy, thank God! There’s still a good chance this will blow over and not affect the U.S. in a major way.

BUT…

If coronavirus becomes an epidemic in the U.S., you will want to be prepared. You’ll want to avoid unnecessary contact with others, especially if you’re over 65 or have significant chronic medical conditions like heart disease, COPD, asthma, active cancer, impaired liver or kidney function, or a poor immune system (e.g, cancer chemotherapy).

If your city or neighborhood is quarantined, will supply trucks be allowed through the checkpoints? Will drivers be willing to enter the quarantine zone? I’ve started to call Wal-Mart, “China-Mart.” Because is it seems like at least half the goods there are made in China. China’s industrial output has already been reduced by the coronavirus epidemic there. A significant number of prescription drugs in the U.S. depend on a healthy China.

A severe coronavirus outbreak in the U.S. might mean you need to hunker down at home, or close to it, for one or two months. So consider stocking up on the following items to last for 4–6 weeks. The good new is, you’ll eventually use most of this anyway.

  • various foods with a long shelf-life
  • face masks (you’re too late; this ship has already sailed)
  • toilet paper
  • paper towels
  • over-the-counter cold and flu remedies
  • acetaminophen
  • ibuprofen
  • throat lozenges
  • antiseptic wipes
  • toothpaste
  • a multivitamin
  • hand sanitizer
  • facial tissues
  • important prescription medicines (you may need to call your doctor for a three-month supply)
  • body soap
  • dishwashing and clothing detergents
  • feminine hygeine products
  • household cleaning products

Have I missed anything?

Steve Parker, M.D.

Update on March 3, 2020: hand sanitizer (60+% alcohol)

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Fasting: Not Ready for Prime Time?

This caveman probably went days without food, and often

Dr Axel Sigurdsson published an epic post on intermittent fasting early in 2020. I don’t doubt anything in it although I haven’t yet taken a deep dive into the subject like he has. I touched on it here, here, here, and here. I’ve done some 24-hour fasting myself (here and here).

From the good doctor:

Animal studies suggest that intermittent fasting may have several health benefits. Some of these benefits, in particular, the effects on obesity, type 2 diabetes, and cardiovascular risk factors, have been confirmed in studies on humans.

However, the popularity of intermittent fasting within the general public is in stark contrast with the gaps in evidence on the clinical benefits of this approach.

Source: Intermittent Fasting and Health – The Scientific Evidence

Steve Parker, M.D.

PS: PWDs taking drugs that can cause hypoglycemia would have to be extremely careful about fasting, working with their doctors or CDEs.

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Here’s Why U.S. Healthcare Is So Expensive

U.S. healthcare needs to be resuscitated

The U.S. has a presidential and other federal elections later this year. So we’ll be hearing more talk about healthcare reform. Mostly talk, not much action. Healthcare is an issue because it soaks up 18% of GDP (Gross Domestic Product). Many of us think that’s way too much and we can’t afford it anymore. Most other fully developed Western nations spend 9–11% of GDP on healthcare. Are we in the U.S. getting our money’s worth? Probably not, if you look at things like longevity, infant mortality rates, and overall disease burden.

When I aim to cure a disease, it helps immensely if I know the cause of the disease. That determines the treatment plan. If we want to fix over-spending on healthcare, we need to know the causes. With the right treatment plan, we might get healthcare costs down to 5% of GDP.

On the other hand, perhaps we in the U.S. love spending 18% of GDP on healthcare. It provides a lot of jobs. I personally make a very nice living with it. Nowhere near the $7.7 million/year of the average NBA player or $2.7 million/year for the average NFL player. At least I know I’m saving lives and alleviating suffering.

Here are the causes of overly-expensive healthcare:

  • Lack of price transparency
  • Third-party payer between patient and provider (they must be paid). Third party may not care about cost; just pass it on via premiums, or insulate themselves via high deductibles.
  • Defensive Medicine: excessive testing and consultations, malpractice insurance premiums, time away from patient care
  • Excessive regulation
  • Government essentially mandates Emergency Department care regardless of ability to pay
  • Excessive administrative costs (bureaucracy) of a byzantine system: providers’ office, healthcare insurance, hospital administration, regulators
  • Lobbying protects insurers, doctors, hospitals, Big Pharma at the expense of consumers
  • Low or no deductibles (no skin in the game)
  • Little incentive for patient to get or stay healthy
  • Government and insurers pay lousy docs the same fee as good doctors, so no incentive for great care or innovation. If you want to improve healthcare, you must financially reward competent and successful competitors. 
  • Providers are incentivized to provide services: provide more services, earn more pay
  • Greed
  • Insurance mandates
  • Government price controls (Medicare and Medicaid)
  • Inadequate competition among providers
  • Un-enforced anti-trust and consumer protection laws 
  • Excessive drug costs
  • Over-utilization of specialist care instead of primary care
  • Laws prevent importation of drugs by patients or providers from cheaper markets
  • Insurance companies prohibited from selling across state lines?
  • Pharmacy Benefits Management Co’s
  • Insurance pays for too much, instead of only catastrophic care?
  • Waste and fraud?
  • Monopolies or near-monopolies (e.g., dominant hospital systems, insurance companies)?

If I’ve missed anything, please leave it in a comment below or email me at steveparkermd[at]gmail[dot]com.

Steve Parker, M.D.

PS: Below are some interesting links I found while researching this post.

From Investopedia in 2019:

“Even with all this money being spent on healthcare, the World Health Organization ranked the U.S. 37th in healthcare systems, and The Commonwealth Fund placed the U.S. last among the top 11 industrialized countries in overall healthcare.”

 From CNBC.com March 2018:

“The real difference between the American health care system and systems abroad is pricing.”

From JAMA Network March 2018:

“The United States spent approximately twice as much as other high-income countries on medical care, yet utilization rates in the United States were largely similar to those in other nations. Prices of labor and goods, including pharmaceuticals, and administrative costs appeared to be the major drivers of the difference in overall cost between the United States and other high-income countries.”

Yale Insights 2016 report focusing on hospitals:

“This study tells us that insurance premiums are so high because healthcare provider prices are incredibly high. The way to rein in the cost of healthcare services is by targeting the massive variation in providers’ prices. We can do that by making prices more transparent, making these markets more dynamic, and really blunting the monopoly power that a lot of large healthcare providers have, which has allowed them to raise prices.” Interviewee says the hospital industry is 8% of GDP.

PPS: Why not do everything you can to get and stay healthy, hopefully keeping you out of the Medical-Industrial Complex? If you need weight loss and exercise, I can help…

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Prevent Dementia With This Healthy Lifestyle

Yes, some cases of dementia are preventable. If you have a genetic predisposition to develop dementia, the deck is stacked against you. But it’s not hopeless. A healthy lifestyle will help you, too.

The research at hand was done in the UK and involved over 500,000 older adults of European ancestry, free of dementia and cognitive impairment at baseline.

So what are the healthy lifestyle characteristics linked to lower risk of dementia, whether you have genetic risk or not?

  • Physical activity
  • Not smoking
  • Healthy diet
  • Judicious alcohol consumption

Lifestyle details from the research report:

A healthy lifestyle score was constructed based on 4 well-established dementia risk factors (smoking status, physical activity, diet, and alcohol consumption) assessed at baseline using a touchscreen questionnaire. Participants scored 1 point for each of 4 healthy behaviors defined on the basis of national recommendations (full details in eTable 1 in Supplement 1). Smoking status was categorized as current or no current smoking. Regular physical activity was defined as meeting the American Heart Association recommendations of at least 150 minutes of moderate activity per week or 75 minutes of vigorous activity per week (or an equivalent combination) or engaging in moderate physical activity at least 5 days a week or vigorous activity once a week. Healthy diet was based on consumption of at least 4 of 7 commonly eaten food groups following recommendations on dietary priorities for cardiometabolic health, which are linked to better late-life cognition and reduced dementia risk. Previous studies of alcohol consumption and dementia risk support a U-shaped relationship, with moderate consumption associated with lower risk. Therefore, moderate consumption was defined as 0 to 14 g/d for women and 0 to 28 g/d for men, with the maximum limit reflecting US dietary guidelines.

Source: Association of Lifestyle and Genetic Risk With Incidence of Dementia | Dementia and Cognitive Impairment | JAMA | JAMA Network

What do they consider a healthy dementia-preventing diet? At least four of the following food groups and consumption levels:

  • Fruits: 3 or more servings a day
  • Veggies: 3 or more servings a day
  • Fish: 2 or more servings a week
  • Processed meats: no more than 1 serving a week
  • Unprocessed red meats: no more than 1.5 servings a week
  • Whole grains: 3 or more servings a day
  • Refined grains: no more than 1.5 servings a day

Regarding alcohol, the guideline is no more than one drink a day for women, and no more than two a day for men. Do a web search for standard drink sizes if needed. “One drink” is 14 grams of pure alcohol.

Steve Parker, M.D.

PS: You do know that the Mediterranean diet is linked to lower risk of dementia, don’t you?

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Alarming Rise In Suicides Among Young Americans

This too shall pass

From The New York Times:

After declining for nearly two decades, the suicide rate among Americans ages 10 to 24 jumped 56 percent between 2007 and 2017, according to data from the Centers for Disease Control and Prevention. And for the first time the gender gap in suicide has narrowed: Though the numbers of suicides are greater in males, the rates of suicide for female youths increased by 12.7 percent each year, compared with 7.1 percent for male youths.

If you or someone you know needs help dealing with suicidal thought, please please please contact the National Suicide Prevention Lifeline at 1-800-273-8255.

Steve Parker, M.D.

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High Protein Diet May Prevent Weight Regain

Filet mignon and sautéed asparagus

Weight loss can change your metabolism in such a way that promotes regain of lost weight. For successful weight-losers with prediabetes, a higher protein diet could help with prevention of regain. How much higher protein? 25% versus the usual 15% of calories from fat.

This is important research since most people who lose fat weight gain it back, typically 6–12 months later.

For the boring details, keep reading.

ABSTRACT

Background

Weight loss has been associated with adaptations in energy expenditure. Identifying factors that counteract these adaptations are important for long-term weight loss and weight maintenance.

Objective

The aim of this study was to investigate whether increased protein/carbohydrate ratio would reduce adaptive thermogenesis (AT) and the expected positive energy balance (EB) during weight maintenance after weight loss in participants with prediabetes in the postobese state.

Methods

In 38 participants, the effects of 2 diets differing in protein/carbohydrate ratio on energy expenditure and respiratory quotient (RQ) were assessed during 48-h respiration chamber measurements ∼34 mo after weight loss. Participants consumed a high-protein (HP) diet (n = 20; 13 women/7 men; age: 64.0 ± 6.2 y; BMI: 28.9 ± 4.0 kg/m 2) with 25:45:30% or a moderate-protein (MP) diet (n = 18; 9 women/9 men; age: 65.1 ± 5.8 y; BMI: 29.0 ± 3.8 kg/m 2) with 15:55:30% of energy from protein:carbohydrate:fat. Predicted resting energy expenditure (REEp) was calculated based on fat-free mass and fat mass. AT was assessed by subtracting measured resting energy expenditure (REE) from REEp. The main outcomes included differences in components of energy expenditure, substrate oxidation, and AT between groups.

Results

EB (MP = 0.2 ± 0.9 MJ/d; HP = −0.5 ± 0.9 MJ/d) and RQ (MP = 0.84 ± 0.02; HP = 0.82 ± 0.02) were reduced and REE (MP: 7.3 ± 0.2 MJ/d compared with HP: 7.8 ± 0.2 MJ/d) was increased in the HP group compared with the MP group (P < 0.05). REE was not different from REEp in the HP group, whereas REE was lower than REEp in the MP group (P < 0.05). Furthermore, EB was positively related to AT (rs = 0.74; P < 0.001) and RQ (rs = 0.47; P < 0.01) in the whole group of participants.

Conclusions

In conclusion, an HP diet compared with an MP diet led to a negative EB and counteracted AT ∼34 mo after weight loss, in participants with prediabetes in the postobese state. These results indicate the relevance of compliance to an increased protein/carbohydrate ratio for long-term weight maintenance after weight loss. The trial was registered at clinicaltrials.gov as NCT01777893.

Source: High Compared with Moderate Protein Intake Reduces Adaptive Thermogenesis and Induces a Negative Energy Balance during Long-term Weight-Loss Maintenance in Participants with Prediabetes in the Postobese State: A PREVIEW Study | The Journal of Nutrition | Oxford Academic

Steve Parker, M.D.

PS: I didn’t read the whole study. I leave that to you.

low-carb mediterranean diet

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Exercise Cuts Your Risk of Cancer by Up to 25%

Exercise is a fountain of youth available to every one

From UPI:

In findings published Thursday in the Journal of Clinical Oncology, researchers at the National Cancer Institute, the American Cancer Society, and the Harvard T.H. Chan School of Public Health report that people who engaged in physical activity as recommended by the National Institutes of Health were able to reduce their risk for seven different types of cancer by as much as 25 percent.

This included common—and deadly—forms of the disease like colon and breast cancers, as well as endometrial cancer, kidney cancer, myeloma, liver cancer, and non-Hodgkin lymphoma.

*  *  *

Updated federal guidelines for physical activity recommend that people should aim for two and a half to five hours per week of moderate-intensity activity or 75 to 150 minutes per week of “vigorous activity.”

Source: Exercise may reduce risk for cancer by as much as 25 percent – UPI.com

You can also reduce your risk of cancer by eating the traditional Mediterranean diet smoking, by not drinking excessive alcohol, and by not smoking.

Steve Parker, M.D.

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U.S. Life Expectancy Is Decreasing

Advanced civilizational decline

Sir John Glubb studied various empires that existed over the last 4,000 years. He deduced that empires have predictable lifecycles, from origin to ascendence, to great power then decline and collapse. I’m not the only one to notice that the U.S. may be on the decline. Decreasing life expectancies are a potential marker of decline. Glubb died in 1986 at the age of 88. He lived through the decline of the British Empire.

From JAMA Network:

US life expectancy increased for most of the past 60 years, but the rate of increase slowed over time and life expectancy decreased after 2014. A major contributor has been an increase in mortality from specific causes (eg, drug overdoses, suicides, organ system diseases) among young and middle-aged adults of all racial groups, with an onset as early as the 1990s and with the largest relative increases occurring in the Ohio Valley and New England. The implications for public health and the economy are substantial, making it vital to understand the underlying causes.

Source: Life Expectancy and Mortality Rates in the United States, 1959-2017 | Population Health | JAMA | JAMA Network

Steve Parker, M.D.

PS: Maybe we’d live longer if we ate food congruent with our evolution instead ultra-processed man-made foods.

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Dr David Ludwig Calls for More Research on Ketogenic Diets

Sous vide chicken and sautéed sugar snap peas. This meal is part of a ketogenic diet.

From The Journal of Nutrition:

Recently, ketogenic diets have received substantial attention from the general public and nutrition research community. These very-low-carbohydrate diets, with fat comprising >70% of calories, have been dismissed as fads. However, they have a long history in clinical medicine and human evolution. Ketogenic diets appear to be more effective than low-fat diets for treatment of obesity and diabetes. In addition to the reductions in blood glucose and insulin achievable through carbohydrate restriction, chronic ketosis might confer unique metabolic benefits of relevance to cancer, neurodegenerative conditions, and other diseases associated with insulin resistance. Based on available evidence, a well-formulated ketogenic diet does not appear to have major safety concerns for the general public and can be considered a first-line approach for obesity and diabetes. High-quality clinical trials of ketogenic diets will be needed to assess important questions about their long-term effects and full potential in clinical medicine.

Source: Ketogenic Diet: Evidence for Optimism but High-Quality Research Needed | The Journal of Nutrition | Oxford Academic

Steve Parker, M.D.

PS: Click the pic below or here for a ketogenic diet.

low-carb mediterranean diet

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