Diabetes Daily Article: Coronavirus and Diabetes

How old is this device?

From Dr Muccioli at Diabetes Daily:

Why are people with diabetes more vulnerable to infections and complications of infections? It has been shown that people with diabetes are at a higher risk for infections and related complications, and, in particular, for various bacterial infections. Although the reasons for this are not completely elucidated yet and are likely multifactorial, research has shown that high blood glucose levels can directly and negatively impact the immune system and that  “…good control of blood sugar in diabetic patients is a desirable goal in the prevention of certain infections and to ensure maintenance of normal host defense mechanisms that determine resistance and response to infection.”As it relates to the COVID-19 outbreak, it follows that maintaining target blood glucose levels is an important preventative strategy for avoiding serious related complications, such as a secondary bacterial infection (i.e., pneumonia) and is likely an important determinant in the patient prognosis for anyone who becomes infected.

Source: Coronavirus & Diabetes: Your Questions Answered – Diabetes Daily

Read the whole thing.

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Exactly WHO Is at Risk of Serious Illness From #CoronaVirus? #COVID-19

“Am I gonna make it, doc?”

The U.S. Centers for Disease Control website notes that the you are at risk for serious—even life-threatening—illness from Coronavirus if you are over age 60–65 or have a serious chronic medical condition, like…

  • heart disease
  • diabetes
  • kidney disease
  • lung disease

Well, there are at least a couple hundred heart diseases, a couple hundred kidney diseases, a couple hundred lung diseases, and at least three kinds of diabetes. There are entire thick medical textbooks written specifically for heart disease, lung disease, and kidney disease. All of those individual diseases don’t make you particularly vulnerable to Coronavirus.

And what’s a “serious condition?” Doctors don’t always tell you how serious a disorder is, and patients don’t always hear and remember when the doctor does. So you have a heart murmur. It’s likely chronic but is it serious? It depends.

I’ve even seen hypertension listed as a risk factor for serious flu complications, but I don’t believe it.

And what’s chronic? Say five years ago you had a mild heart attack, a stent was put in the only blocked artery, you take your prescribed drugs, and your doctor told you last month you’re doing great. Do you still have a serious chronic medical ailment?

How Do I Know If I Have a Serious Chronic Medical Condition?

If you’re uncertain, the answer should come from your personal medical specialist or primary care physician. I know many of you will be unsure.

Here’s a simple test you can do to see if you might have a serious chronic medical condition:

  • Walk up two flights of stairs without stopping

If you can’t do that without stopping to rest and without much shortness-of-breath (you should be easily able to carry on a conversation): you flunk. Possible explanations (among many) include serious heart or lung disease, being badly overweight, or just “out of shape” from lack of regular exercise. A couple of those conditions you can rectify, and should.

Artist’s rendition of Coronavirus (plus red blood cells, which in reality are orders of magnitude larger than viruses)

If You Have One of the Following Conditions, You Need to Be Extra Careful When Coronavirus Is Around

Having practiced medicine for over three decades—and I’ll keep practicing until I get it right—here’s my current list of conditions that raise your risk of serious disease if you contract Coronavirus:

  • age over 60–65 (may not be much of a risk factor if you are otherwise healthy, physically fit, and eat well)
  • needing supplemental oxygen at home, whether continuously, at night only, or just as needed
  • moderate or severe valvular heart disease, whether the valve is leaky or blocked
  • a weak heart muscle called cardiomyopathy with left ventricular ejection fraction under 50% or on home oxygen
  • history of congestive heart failure with current left ventricular ejection fraction under 50% or on home oxygen
  • moderate to severe diastolic heart failure (sometimes call “heart failure with preserved ejection fraction”)
  • serious coronary artery disease (e.g., frequent chest pains, multiple heart attacks, residual blockages in arteries)
  • asthma that requires daily drugs or that has frequent or severe exacerbations
  • COPD (chronic obstructive pulmonary disease) or emphysema requiring daily scheduled drugs or frequent “as needed” drugs or home oxygen
  • chronic liver disease (such as cirrhosis) with serum bilirubin over 2.0 mg/dL or albumin under 3.0 g/dL or elevated prothrombin time
  • serious active cancer, particularly if on chemotherapy that suppresses the immune system
  • prior organ transplant requiring immunosuppressive drug therapy to prevent organ rejection
  • immunoglobulin deficiency
  • very sedentary lifestyle
  • poor nutrition and/or malnutrition
  • morbid obesity
  • body mass index over 35
  • on chronic corticosteroid therapy
  • end-stage renal disease on dialysis
  • chronic kidney disease with serum creatinine over 2 mg/dL
  • nephrotic syndrome
  • diabetes mellitus, especially if poorly controlled and/or concomittant chronic organ impairment such as nephropathy, neuropathy, or retinopathy
  • active autoimmune disease (e.g., systemic lupus erythematosis, rheumatoid arthritis, Crohn’s disease), particularly if on drug therapy that impairs immune system function
  • chronic low white blood cell count
  • chronic active infection (e.g., tuberculosis, hepatitis, AIDS)
  • you “always catch what’s going around” (possible immune system disorder or poor hygeine?)

Why Do These Conditions Increase Risk of Serious Illness?

Many of these infirmities impair your immune system and increase your risk of serious complications from any infection, whether viral, bacterial, or fungal. Just as importantly, these disorders may impair your body’s ability to respond to the increased physical stress of infection. Clearly, the more of these ailments you have, the greater your chance of a bad outcome.

Here’s the problem when you come down with flu or any other infection. The infection increases the workload on various organ systems that keep you alive day in and day out. Even if you take an antibiotic or anti-viral drug, you still need various organ systems to keep you alive. I’m thinking particularly about your lungs, cardiovascular, and immune systems, working together at maximal capacity. You heart, for example, pumps about five liters of blood every minute while you’re at rest, blood that’s carrying life-preserving oxygen to all your other organs in addition to the heart muscle. That blood also carries a waste product—carbon dioxide—to your lungs for delivery to the outside world. If you exercise vigorously your heart increases it’s pumping output to twenty liters a minute, if you’re young and healthy. By the same token, your lungs have a certain but limited capacity to take up oxygen from the air and blow off carbon dioxide both at rest and during exercise. As we age, the capacity the heart and lungs to do their jobs diminishes no matter what. Same with the immune system. That’s why folks over 60 are at risk for serious complications from viral and other infections. Because infections increase the workload on the heart, lungs, and immune system. When Coronavirus infects your lungs, fluid and inflammatory debris builds up in the gas-exchanging tissues, impairing your ability to absorb oxygen from the air. So your lungs and heart have to work harder, and long enough for your immune system to eradicate there virus.

I hope you find this list more helpful than CDC’s. Nevertheless, I’m sure it’s incomplete. I’m not trying to scare you. I’m trying to help you survive the pandemic, as most of us will. Forewarned in forearmed.

Steve Parker, M.D.

PS: It’s still very early in this pandemic and there’s much we don’t know. Stay tuned.

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Mediterranean Diet Wins #1 Rank Once Again #MediterraneanDiet

Santorini, Greek seaside

Not surprising!

Every year, the U.S. News and World Report puts together a panel of experts to rank various diets.

From MedScape:

For the third year in a row, the Mediterranean diet has been named the best diet overall in the U.S. News & World Report annual rankings.

In 2018, the Mediterranean diet shared top honors with the DASH (Dietary Approaches to Stop Hypertension) diet. Both focus on fruits, vegetables, and whole grains. The ketogenic diet, one of the most popular, again fared well in the annual survey, but only in the fast weight loss category. Overall, it was not rated highly.

Angela Haupt, managing editor of health for the publication, says this year’s list has ”no surprises,” as it includes many diets that have been named outstanding before. Trendy diets typically won’t be found on its list, she says, explaining that its experts look for plans that have solid research and staying power.

Source: Mediterranean Diet Repeats as Best Overall of 2020

Steve Parker, M.D.

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If You Have T2 Diabetes, Odds Are Good That You Already Have Fatty Liver (NAFL)

Stages of liver damage: healthy, fatty, liver fibrosis, and cirrhosis. 

I’ve written before about fatty liver here, here, and here, for example. Fatty liver by itself may not be very harmful but sometimes it progresses to liver inflammation called steatohepatitis. Which can lead to cirrhosis. Non-alcoholic fatty liver disease is the second leading cause for liver transplantation in the U.S., after viral hepatitis.

You only have one liver, so be nice to it.

How common is fatty liver in the U.S. among those with T2 diabetes? From Diabetes Care:

The overall prevalence of NAFLD [non-alcoholic fatty liver disease] was >70% (47% with NAFL [non-alcoholic fatty liver] plus 26% with NASH [non-alcoholic steatohepatitis], for a total of >18 million patients with T2D having NAFLD (not including patients in the U.S. with undiagnosed T2D).

Source: Time to Include Nonalcoholic Steatohepatitis in the Management of Patients With Type 2 Diabetes | Diabetes Care

Steve Parker, M.D.

PS: One way to get fat out of your liver is to lose excess fat body weight. Let me help you.

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Are Your Drugs So Expensive Due to PBMs?

Compared to Europe and Canada, drugs are about 10 times more expensive in the U.S.

The American Prospect has an eye-opening article from 2017 that sheds light on pharmacy benefits managers (PBMs). Ever heard of them?

Author David Dayen starts with comments from pharmacy owner Frankil talking about how he determines how much money he makes on retail sale of a drug:

Like any retail outlet, Frankil purchases inventory from a wholesale distributor and sells it to customers at a small markup. But unlike butchers or hardware store owners, pharmacists have no idea how much money they’ll make on a sale until the moment they sell it. That’s because the customer’s co-pay doesn’t cover the cost of the drug. Instead, a byzantine reimbursement process determines Frankil’s fee.

“I get a prescription, type in the data, click send, and I’m told I’m getting a dollar or two,” Frankil says. The system resembles the pull of a slot machine: Sometimes you win and sometimes you lose. “Pharmacies sell prescriptions at significant losses,” he adds. “So what do I do? Fill the prescription and lose money, or don’t fill it and lose customers? These decisions happen every single day.”

Frankil’s troubles cannot be traced back to insurers or drug companies, the usual suspects that most people deem responsible for raising costs in the health-care system. He blames a collection of powerful corporations known as pharmacy benefit managers, or PBMs. If you have drug coverage as part of your health plan, you are likely to carry a card with the name of a PBM on it. These middlemen manage prescription drug benefits for health plans, contracting with drug manufacturers and pharmacies in a multi-sided market. Over the past 30 years, PBMs have evolved from paper-pushers to significant controllers of the drug pricing system, a black box understood by almost no one. Lack of transparency, unjustifiable fees, and massive market consolidations have made PBMs among the most profitable corporations you’ve never heard about.

***

In the case of PBMs, their desire for larger patient networks created incentives for their own consolidation, promoting their market dominance as a means to attract customers. Today’s “big three” PBMs—Express Scripts, CVS Caremark, and OptumRx, a division of large insurer UnitedHealth Group—control between 75 percent and 80 percent of the market, which translates into 180 million prescription drug customers. All three companies are listed in the top 22 of the Fortune 500, and as of 2013, a JPMorgan analyst estimated total PBM revenues at more than $250 billion.

***

PMBs initially came about as a means of saving costs. Why hasn’t that panned out?

The biggest reason experts cite is an information advantage in the complex pharmaceutical supply chain.

***

This lack of transparency enables PBMs to enjoy multiple hidden revenue streams from every other player. “It’s OK to have intermediaries, we have Visa,” says David Balto, an antitrust litigator and former top official with the Federal Trade Commission. “But these companies make a fabulous amount of money, even though they’re not buying the drug, not producing the drug, not putting themselves at risk.”

The PBM industry is rife with conflicts of interest and kickbacks. For example, PBMs secure rebates from drug companies as a condition of putting their products on the formulary, the list of reimbursable drugs for their network. However, they are under no obligation to disclose those rebates to health plans, or pass them along. Sometimes PBMs call them something other than rebates, using semantics to hold onto the cash. Health plans have no way to obtain drug-by-drug cost information to know if they’re getting the full discount.

***

It’s a long article and I confess I haven’t read the whole thing yet. I’ve read enough to rile up my sense of indignation! Pharmaceutical companies and health insurers don’t seem too upset. Because costs associated with these third-party shenanigans is simply passed on to the consumer—that’s you—in higher insurance premiums, deductibles, and co-pays.

Steve Parker, M.D.

PS: Reduce your needs for drugs with a healthy diet and lifestyle. I can help.

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Alcohol Is Killing Too Many of Us

Irish Whiskey.

According to the National Institute of Alcohol Abuse and Alcoholism, a recent scientific paper found an alarming increase in deaths related to alcohol:

The researchers found that, in 2017, nearly half of alcohol-related deaths resulted from liver disease (31%; 22,245) or overdoses on alcohol alone or with other drugs (18%; 12,954). People aged 45-74 had the highest rates of deaths related to alcohol, but the biggest increases over time were among people age 25-34. High rates among middle-aged adults are consistent with recent reports of increases in “deaths of despair,” generally defined as deaths related to overdoses, alcohol-associated liver cirrhosis, and suicides, primarily among non-Hispanic whites. However, the authors report that, by the end of the study period, alcohol-related deaths were increasing among people in almost all age and racial and ethnic group.

As with increases in alcohol consumption and related medical emergencies, rates of death involving alcohol increased more for women (85%) than men (35%) over the study period, further narrowing once large differences in alcohol use and harms between males and females. The findings come at a time of growing evidence that even one drink per day of alcohol can contribute to an increase in the risk of breast cancer for women. Women also appear to be at a greater risk than men for alcohol-related cardiovascular diseases, liver disease, alcohol use disorder, and other consequences.

“Alcohol is a growing women’s health issue,” said Dr. Koob. “The rapid increase in deaths involving alcohol among women is troubling and parallels the increases in alcohol consumption among women over the past few decades.”

Source: Alcohol-related deaths increasing in the United States | National Institute on Alcohol Abuse and Alcoholism (NIAAA)

I’ve written about adverse effects of alcohol consumption, and who shouldn’t drink alcohol at all.

Steve Parker, M.D.

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Metformin: New Uses for an Old Drug

Metformin? A shirt from 1967?

Medical Xpress has an article about the possible future uses of metformin for weight loss, prostate cancer treatment, and tuberculosis treatment. It didn’t mention metformin as an anti-aging drug.

From the article:

Among medications, metformin has a long and storied past. The compound destined to become metformin was first isolated during the Middle Ages from the French lilac, a plant scientifically known as Galega officinalis. Ground flowers and leaves were administered by healers to patients suffering from constant urination, a hallmark of a disorder that later would become known as diabetes. The active ingredient in French lilac, a plant also called goat’s rue, was identified hundreds of years later as galegine, which triggered a striking reduction in blood glucose.

By the 1950s, scientists were able to exploit folk medicine uses and develop the drug that became metformin.

Source: Wonder drug? Exploring the molecular mechanisms of metformin, a diabetes drug with Medieval roots

Don’t believe everything you read. The article claims metformin’s effectiveness in type 2 diabetes is primarily due to weight loss. Conventional thinking is that it’s mostly due to decreased production and release of glucose by the liver. I guess time will tell which theory wins out. In either case, it’s a good initial drug for T2 diabetes if diet and exercise prove inadequate.

Steve Parker, M.D.

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Prepare Your Household for Coronavirus

Advanced civilizational collapse

I hadn’t been too concerned about coronavirus (COVID-19), but then I read about quarantined towns in northern Italy. I’m still not terribly worried for my own health, even if I end up treating cases at the hospital. I’m 65—a risk factor for viral death—but otherwise healthy, thank God! There’s still a good chance this will blow over and not affect the U.S. in a major way.

BUT…

If coronavirus becomes an epidemic in the U.S., you will want to be prepared. You’ll want to avoid unnecessary contact with others, especially if you’re over 65 or have significant chronic medical conditions like heart disease, COPD, asthma, active cancer, impaired liver or kidney function, or a poor immune system (e.g, cancer chemotherapy).

If your city or neighborhood is quarantined, will supply trucks be allowed through the checkpoints? Will drivers be willing to enter the quarantine zone? I’ve started to call Wal-Mart, “China-Mart.” Because is it seems like at least half the goods there are made in China. China’s industrial output has already been reduced by the coronavirus epidemic there. A significant number of prescription drugs in the U.S. depend on a healthy China.

A severe coronavirus outbreak in the U.S. might mean you need to hunker down at home, or close to it, for one or two months. So consider stocking up on the following items to last for 4–6 weeks. The good new is, you’ll eventually use most of this anyway.

  • various foods with a long shelf-life
  • face masks (you’re too late; this ship has already sailed)
  • toilet paper
  • paper towels
  • over-the-counter cold and flu remedies
  • acetaminophen
  • ibuprofen
  • throat lozenges
  • antiseptic wipes
  • toothpaste
  • a multivitamin
  • hand sanitizer
  • facial tissues
  • important prescription medicines (you may need to call your doctor for a three-month supply)
  • body soap
  • dishwashing and clothing detergents
  • feminine hygeine products
  • household cleaning products

Have I missed anything?

Steve Parker, M.D.

Update on March 3, 2020: hand sanitizer (60+% alcohol)

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Fasting: Not Ready for Prime Time?

This caveman probably went days without food, and often

Dr Axel Sigurdsson published an epic post on intermittent fasting early in 2020. I don’t doubt anything in it although I haven’t yet taken a deep dive into the subject like he has. I touched on it here, here, here, and here. I’ve done some 24-hour fasting myself (here and here).

From the good doctor:

Animal studies suggest that intermittent fasting may have several health benefits. Some of these benefits, in particular, the effects on obesity, type 2 diabetes, and cardiovascular risk factors, have been confirmed in studies on humans.

However, the popularity of intermittent fasting within the general public is in stark contrast with the gaps in evidence on the clinical benefits of this approach.

Source: Intermittent Fasting and Health – The Scientific Evidence

Steve Parker, M.D.

PS: PWDs taking drugs that can cause hypoglycemia would have to be extremely careful about fasting, working with their doctors or CDEs.

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Here’s Why U.S. Healthcare Is So Expensive

U.S. healthcare needs to be resuscitated

The U.S. has a presidential and other federal elections later this year. So we’ll be hearing more talk about healthcare reform. Mostly talk, not much action. Healthcare is an issue because it soaks up 18% of GDP (Gross Domestic Product). Many of us think that’s way too much and we can’t afford it anymore. Most other fully developed Western nations spend 9–11% of GDP on healthcare. Are we in the U.S. getting our money’s worth? Probably not, if you look at things like longevity, infant mortality rates, and overall disease burden.

When I aim to cure a disease, it helps immensely if I know the cause of the disease. That determines the treatment plan. If we want to fix over-spending on healthcare, we need to know the causes. With the right treatment plan, we might get healthcare costs down to 5% of GDP.

On the other hand, perhaps we in the U.S. love spending 18% of GDP on healthcare. It provides a lot of jobs. I personally make a very nice living with it. Nowhere near the $7.7 million/year of the average NBA player or $2.7 million/year for the average NFL player. At least I know I’m saving lives and alleviating suffering.

Here are the causes of overly-expensive healthcare:

  • Lack of price transparency
  • Third-party payer between patient and provider (they must be paid). Third party may not care about cost; just pass it on via premiums, or insulate themselves via high deductibles.
  • Defensive Medicine: excessive testing and consultations, malpractice insurance premiums, time away from patient care
  • Excessive regulation
  • Government essentially mandates Emergency Department care regardless of ability to pay
  • Excessive administrative costs (bureaucracy) of a byzantine system: providers’ office, healthcare insurance, hospital administration, regulators
  • Lobbying protects insurers, doctors, hospitals, Big Pharma at the expense of consumers
  • Low or no deductibles (no skin in the game)
  • Little incentive for patient to get or stay healthy
  • Government and insurers pay lousy docs the same fee as good doctors, so no incentive for great care or innovation. If you want to improve healthcare, you must financially reward competent and successful competitors. 
  • Providers are incentivized to provide services: provide more services, earn more pay
  • Greed
  • Insurance mandates
  • Government price controls (Medicare and Medicaid)
  • Inadequate competition among providers
  • Un-enforced anti-trust and consumer protection laws 
  • Excessive drug costs
  • Over-utilization of specialist care instead of primary care
  • Laws prevent importation of drugs by patients or providers from cheaper markets
  • Insurance companies prohibited from selling across state lines?
  • Pharmacy Benefits Management Co’s
  • Insurance pays for too much, instead of only catastrophic care?
  • Waste and fraud?
  • Monopolies or near-monopolies (e.g., dominant hospital systems, insurance companies)?

If I’ve missed anything, please leave it in a comment below or email me at steveparkermd[at]gmail[dot]com.

Steve Parker, M.D.

PS: Below are some interesting links I found while researching this post.

From Investopedia in 2019:

“Even with all this money being spent on healthcare, the World Health Organization ranked the U.S. 37th in healthcare systems, and The Commonwealth Fund placed the U.S. last among the top 11 industrialized countries in overall healthcare.”

 From CNBC.com March 2018:

“The real difference between the American health care system and systems abroad is pricing.”

From JAMA Network March 2018:

“The United States spent approximately twice as much as other high-income countries on medical care, yet utilization rates in the United States were largely similar to those in other nations. Prices of labor and goods, including pharmaceuticals, and administrative costs appeared to be the major drivers of the difference in overall cost between the United States and other high-income countries.”

Yale Insights 2016 report focusing on hospitals:

“This study tells us that insurance premiums are so high because healthcare provider prices are incredibly high. The way to rein in the cost of healthcare services is by targeting the massive variation in providers’ prices. We can do that by making prices more transparent, making these markets more dynamic, and really blunting the monopoly power that a lot of large healthcare providers have, which has allowed them to raise prices.” Interviewee says the hospital industry is 8% of GDP.

PPS: Why not do everything you can to get and stay healthy, hopefully keeping you out of the Medical-Industrial Complex? If you need weight loss and exercise, I can help…

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