More on Alogliptin (Nesina), the New Drug for Type 2 Diabetes

Alogliptin isn’t revolutionary.  It’s another DPP-4 inhibitor.  The brand name in the U.S. is Nesina.  Before taking it, review potential risks and benefits with your personal physician and pharmacist.  The following info is from the package insert approved by the U.S. Food and Drug Administration.

Who’s It For?

Non-pregnant adults with type 2 diabetes not in ketoacidosis.

What’s the Dose?

25 mg by mouth daily; lower for those with kidney impairment.

Important Side Effects?

Most common are stuffy or runny nose, headache, and upper respiratory infection.  It may cause pancreatitis and liver inflammation.  As usual, allergic reactions are possible.  By itself, alogliptin doesn’t cause hypoglycemia.

Can Alogliptin Be Used With Other Diabetes Drugs?

Yes: metformin, pioglitazone, and insulin (probably sulfonylureas, too, but I’m not sure).

Anything Else?

Alogliptin will be available in three forms: 1) alone, 2) combined with metformin, and 3) combined with pioglitazone.

Steve Parker, M.D.

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