Bladder Cancer Linked With Diabetes Drugs in Thiazolidinedione Class

MedPage Today reports that thiazolidinediones (aka glitazones) are linked to development of bladder cancer.  Pioglitazone is the most commonly used TZD in the U.S.  From the article:

The increased risk of bladder cancer associated with glitazones — which reached a relative increase of 72% in patients who started on the agents more than 5 years earlier — “appears to be a class effect,” the research team, led by Ronac Mamtani, MD, of the University of Pennsylvania in Philadelphia, concluded.

According to the National Cancer Institute, the U.S. has 74,000 new cases of bladder cancer yearly, and 15,000 annual deaths from bladder cancer.

If you take a thiazolidinedione, talk to your doctor about bladder cancer at your next visit.

Steve Parker, M.D.


Filed under cancer, Drugs for Diabetes

4 responses to “Bladder Cancer Linked With Diabetes Drugs in Thiazolidinedione Class

  1. Hi Dr. Steve,

    I found your site through Jamie at The LIghter Side blog. Love your site and the work you’re doing here! I added you to my Cool Sites Page on my blog. Just wanted to let you know!


    (BTW – I’ve been low carbing for 12 years now and have been able to delay progression of my pre-diabetes, post-hysterectomy PCOS through this way of eating. I have lost over 85lbs and still have much more to go and am a breast cancer survivor as of the last 6 months. I successfully lost weight through cancer treatment when most women gain 10-20lbs from all the steroids and chemo!)

    • Susie, thanks for commenting and adding me to your blogroll!
      Jamie’s a special lady, for sure.
      So sorry to hear about your cancer diagnosis. Many folks beat cancer and I surely hope you’re one of them.


  2. Reblogged this on killcancersavebirthdays and commented:
    Hi Everyone, I’m so happy that Dr. Steve Parker touched on the risk of bladder cancer being kinked to glitazones. We all need to be very alert when it comes to cancer because it comes to invade bodies in various ways. The last thing we want to do is, take a drug to cure one problem and develop another. So, please follow Dr. Steve Parker’s advice and ask your doctor to explain the side effect of glitazone.

  3. Pingback: Pioglitazona aumenta o risco de câncer de bexiga em adultos com diabetes tipo 2 « Portal Tuxauas