FDA approves “artificial pancreas” for type 1 diabetes

CNN has a few details on the Medtronic MiniMed 670G, which should be available to consumers this spring:

“The Food and Drug Administration approved a so-called artificial pancreas Wednesday. The first-of-its-kind device, the size of a cell phone, monitors and treats patients with type 1 diabetes, also known as juvenile diabetes.In those with type 1 diabetes, the pancreas does not produce enough insulin, a hormone people need to get energy from food. The Medtronic MiniMed 670G system continuously monitors glucose (blood sugar) levels and delivers needed insulin to patients.

“This is a revolutionary day for the treatment of diabetes. We’ve been long awaiting the artificial pancreas, and it’s exciting to see it,” said Dr. Robert Courgi, an endocrinologist at Northwell Health’s South Side Hospital in Bay Shore, New York.”

Source: ‘Artificial pancreas’ for type 1 diabetes wins FDA approval – CNN.com

Cost and insurance coverage issues should be interesting.

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Overweight Women Lose More Weight If Main Meal Is Lunch Rather Than Dinner

Conquer Diabetes and Prediabetes, Steve Parker MD

It may not matter whether you eat this particular low-carb meal at lunch or dinner

They say that to lose excess weight, you should eat breakfast like a king, lunch like a prince, and dinner like a pauper.

A recent study tested whether weight loss in dieting women was more effective by making lunch rather than dinner (evening meal) the main meal of the day. Over the course of 12 weeks, dieters making lunch their main meal lost 4 lb (2 kg) more than the other group. Furthermore, the lunch eaters had better improvement in their insulin resistance (as measured by HOMA-IR)

From the abstract:

“Background: The association between the time of nutrient intake and health has been described in a few studies. To our knowledge, no study has evaluated the relation between high energy intakes at lunch compared with at dinner on weight loss in overweight and obese subjects.

Objective: We compared the effect of high energy intake at lunch with that at dinner on weight loss and cardiometabolic risk factors in women during a weight-loss program.Design: Overweight and obese women [n = 80; body mass index (BMI; in kg/m2): 27–35; age: 18–45 y] were asked to eat either a main meal at lunch (LM) or a main meal at dinner (DM) for 12 wk while in a weight-loss program.

Conclusions: The consumption of higher energy intake at lunch compared with at dinner may result in favorable changes in weight loss in overweight and obese women after a weight-loss program of 12 wk. The consumption may also offer clinical benefits to improve insulin resistance.”

Source: Beneficial effect of high energy intake at lunch rather than dinner on weight loss in healthy obese women in a weight-loss program: a randomized clinical trial

I don’t have the full text of the research report, so I don’t know what kind of diet the women were on. The researchers seem to be based in both Iran and Great Britain. I don’t know the nationality of the women participating. The metabolism of Iranians may be different from Brits.

Steve Parker, M.D.

 

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Harriet Hall on Plavinol and Other Natural Remedies for Diabetes

Harriet Hall, M.D., looked at the evidence for Plavinol as a diabetes treatment. She’s skeptical about it:

“In a recent article on SBM, Scott Gavura quoted a pharmacy customer who said “I don’t want to take any drugs. Do you have something natural I can use to cut my blood sugar?” Scott went on to cover the questionable evidence for cinnamon in that article. Many other “natural” remedies have been proposed. Here’s an alphabetical list: acetyl L-carnitine, aloe, alpha-lipoic acid, banaba leaf (not banana!), basil, berberine, bilberry, biotin, bitter melon, cinnamon, chromium, coQ10, crepe myrtle, fenugreek, fish oil, fructo-oligosaccharides, green tea, ginseng, glucomannan, gymnema, hibiscus, Indian kino tree extract, magnesium, mistletoe, olive leaf, onion, psyllium, purslane, resveratrol, starch blockers, thiamine, vanadium, and vitamins. I compiled that list from just three websites; I’m sure there are many more natural remedies that I missed. These natural remedies have been recommended on the basis of rather shaky preliminary evidence that they lower blood sugar, usually by only a small amount. Even the CAM-friendly National Center for Complementary and Integrative Health (NCCIH) concluded: “There is not enough scientific evidence to suggest that any dietary supplements can help prevent or manage type 2 diabetes.”

Source: Plavinol and Other Natural Remedies for Diabetes: “Condimentary Medicine”? « Science-Based Medicine

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P.D. Mangan on Processed Food, Supernormal Stimuli, and Obesity 

Supernormal stimulus

Supernormal stimulus

Read the whole thing (link below). It’s not long. A snippet:

“The obesogenic nature of the kind of foods that most people eat means that you must largely avoid them.

Because of the supernormal stimuli embedded in them, the best course of action in my opinion is to avoid them at all costs. Supernormal stimuli cause addiction, and they may make your steak and eggs, foods that you should be eating, less appealing.

For most people, unless they have plenty of money to throw around, this means preparing food and eating at home. Avoid the center of the grocery store, where processed junk and soda are sols, and shop around the outside, where you’ll find whole, unprocessed food like meat, cheese, eggs, and vegetables.”

Source: Processed Food, Supernormal Stimuli, and Obesity – Rogue Health and Fitness

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New research: Mediterranean diet linked to reduced risk of cardiovascular disease and death

This tower is in Pisa, Italy

This tower is in Pisa, Italy

This won’t surprise you if you’ve been reading this blog for a while:

“Heart disease is the leading cause of death for both men and women in the United States, killing around 610,000 people annually. Heart attack affects around 735,000 Americans each year, while around 800,000 people are affected by stroke.

Adopting a healthy diet is considered key for reducing the risk of CVD, and numerous studies have suggested the Mediterranean diet fits the bill.

A study published in the European Heart Journal earlier this year, for example, found older adults who adhered to the Mediterranean diet were at lower risk of heart attack, stroke, and cardiovascular death than those who followed a Western diet.”

Source: Mediterranean diet linked to reduced risk of CVD – Medical News Today

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Is Hunger Really a Problem In the U.S.?

I’m hearing ads on the radio that many in the U.S., including children, are suffering from hunger. Nutrition science journals in the last few years are covering “food insecurity,” which many would assume means not having enough food or fearing the lack of food.

These concerns seem at odds with the fact that two-thirds of us are overweight or obese. So how many of us at normal or below-average weights suffer from food insecurity or hunger?

James Bovard breaks it down for you in an excellent article. Read the whole thing. Some morsels (heh):

  • seven times as many (low income) children are obese as are underweight
  • 40% of food stamp (SNAP) users are obese, compared to 30% in the overall U.S. adult population
  • if the food stamp program would prohibit purchase of sugary drinks, it would prevent 141,000 children from becoming fat and save a quarter million adults from type 2 diabetes

Fat hungry people would be less hungry if they’d cut way back on refined, nutrient-poor carbohydrates, replacing with protein and healthy fats.

Steve Parker, M.D.

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Paleo Diet Improves Metabolic Syndrome

…according to an article at American Journal of Clinical Nutrition.

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“Metabolic syndrome” may be a new term for you. It’s a collection of clinical features that are associated with increased future risk of type 2 diabetes and atherosclerotic complications such as heart attack and stroke. One in six Americans has metabolic syndrome. Diagnosis requires at least three of the following five conditions:

  • high blood pressure (130/85 or higher, or using a high blood pressure medication)
  • low HDL cholesterol: under 40 mg/dl (1.03 mmol/l) in a man, under 50 mg/dl (1.28 mmol/l) in a women (or either sex taking a cholesterol-lowering drug)
  • triglycerides over 150 mg/dl (1.70 mmol/l) (or taking a cholesterol-lowering drug)
  • abdominal fat: waist circumference 40 inches (102 cm) or greater in a man, 35 inches (89 cm) or greater in a woman
    fasting blood glucose over 100 mg/dl (5.55 mmol/l)
  • fasting blood glucose over 100 mg/dl (5.55 mmol/l)

I don’t plan on reading the full text of the report because it’s a meta-analysis and I’ve likely reviewed the four component studies here already. Here are the results:

Four RCTs [randomized controlled trials] that involved 159 participants were included. The 4 control diets were based on distinct national nutrition guidelines but were broadly similar. Paleolithic nutrition resulted in greater short-term improvements than did the control diets (random-effects model) for waist circumference (mean difference: −2.38 cm; 95% CI: −4.73, −0.04 cm), triglycerides (−0.40 mmol/L; 95% CI: −0.76, −0.04 mmol/L), systolic blood pressure (−3.64 mm Hg; 95% CI: −7.36, 0.08 mm Hg), diastolic blood pressure (−2.48 mm Hg; 95% CI: −4.98, 0.02 mm Hg), HDL cholesterol (0.12 mmol/L; 95% CI: −0.03, 0.28 mmol/L), and fasting blood sugar (−0.16 mmol/L; 95% CI: −0.44, 0.11 mmol/L). The quality of the evidence for each of the 5 metabolic components was moderate. The home-delivery (n = 1) and dietary recommendation (n = 3) RCTs showed similar effects with the exception of greater improvements in triglycerides relative to the control with the home delivery. None of the RCTs evaluated an improvement in quality of life.

Ways to improve or cure metabolic syndrome include the paleo diet, Mediterranean diet, low-carb diets, ketogenic diets, and exercise. Losing excess fat weight with any reasonable diet would probably work. Enhance effectiveness by exercising.

Steve Parker, M.D.

Reference:Eric W Manheimer,  Esther J van Zuuren, Zbys Fedorowicz, and Hanno Pijl. Paleolithic nutrition for metabolic syndrome: systematic review and meta-analysis. AJCN. First published August 12, 2015, doi: 10.3945/ajcn.115.113613

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Strength Training Cuts the Risk of Type 2 Diabetes and Cardiovascular Disease In Women

That's a dumbbell in her right hand. I work-out with those myself.

That’s a dumbbell in her right hand. I work-out with those myself.

I don’t have access to the full scientific report, but I’ve posted part of the abstract below.

The biggest problem with the study at hand is that physical activity apparently was surveyed only at the start of this 14-year study. Results would be much more robust if activity was surveyed every year or two. My overall activity level seems to change every two or three years. How about you?

Moving on.

“Compared to women who reported no strength training, women engaging in any strength training experienced a reduced rate of type 2 diabetes of 30% when controlling for time spent in other activities and other confounders. A risk reduction of 17% was observed for cardiovascular disease among women engaging in strength training. Participation in both strength training and aerobic activity was associated with additional risk reductions for both type 2 diabetes and cardiovascular disease compared to participation in aerobic activity only.

CONCLUSIONS: These data support the inclusion of muscle-strengthening exercises in physical activity regimens for reduced risk of type 2 diabetes and cardiovascular disease, independent of aerobic exercise. Further research is needed to determine the optimum dose and intensity of muscle-strengthening exercises.”

PMID 27580152

Source: Strength Training and the Risk of Type 2 Diabetes and Cardiovascular Disease. – PubMed – NCBI

Steve Parker, M.D.

PS: Cardiovascular disease includes heart attack, cardiac death, stroke, coronary angioplasty, and coronary artery bypass grafting.

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diaTribe Asks: How Do We Reduce Diabetes Stigma and Guilt? 

If you suffer stigmatization and guilt about your diabetes, know that you’re not alone.

diaTribe interviewed Dr. Susan Guzman, a psychologist:

One person with type 1 diabetes told Dr. Guzman that when seeking medical consultation, her endocrinologist called her A1c over 6.5% a “failure” and used critical language to discuss her weight; she felt so ashamed that she tried to conceal her diabetes from friends, employers, and strangers. Dr. Guzman urged physicians to cease using harmful messaging, such as “non-compliant,” “unmotivated,” and “failure.” These terms discourage and embarrass rather than motivate; they are often also misguided in origin. Words like “prevention,” “reversible,” and “cure” can also contribute to stigma by inadequately recognizing the long-term efforts and constant decision-making involved in diabetes.

Source: How Do We Reduce Diabetes Stigma and Guilt? | diaTribe

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What’s the Average Weight Gain Around the Upcoming Holidays?

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MNT has the details:

“Around the world, weight gained from holiday feasting takes months to lose, a study found.

Christmas Day in particular is a holiday that appears to pack on the pounds: in a study of some 3,000 individuals in three countries, Americans showed an average 0.4% weight gain from 10 days before Christmas to 10 days after; Germans gained 0.6% more weight; and the Japanese 0.5%.

U.S. participants packed on 0.7% more weight in total during the full Christmas-New Year holiday season, but the Germans had us beat with a 1.0% weight gain, according to Brian Wansink, PhD, of Cornell University in Ithaca, N.Y. and colleagues.”

Source: Holiday Feasts Take Months-Long Weight Toll | Medpage Today

Those percentages aren’t very helpful, are they? In real life, if you weigh 180 lb (81.8 kg) and gain an extra 0.7%, you’re all the way up to a whopping 181.26 lb (82.4 kg). But if you do that—1.26 lb—every year for 20 years and fail to lose the weight, you’re up to 205 lb (93.2 kg) and now you’ve got diabetes and high blood pressure.

Here are a few tips to avoid the weight gain:

  • On the day of the major feast, just eat two meals, and make one of them small
  • Don’t  snack or graze; just eat at mealtimes
  • Work in some extra exercise
  • Minimize the alcohol that weakens your discipline

Steve Parker, M.D.

Pro Tip: Read one of my books before you make your annual New Year’s weight-loss resolutions.

PPS: Click for the research report in NEJM.

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