Comments on: You Know About Insulin. And Now, the REST of the Story . . . http://diabeticmediterraneandiet.com/2010/02/08/glucose-control-by-insulin-amylin-glucagon-glp1-gip/ Conquer Diabetes and Prediabetes With Low-Carb Eating Sat, 19 May 2012 12:43:19 +0000 hourly 1 http://wordpress.com/ By: Steve Parker, M.D. http://diabeticmediterraneandiet.com/2010/02/08/glucose-control-by-insulin-amylin-glucagon-glp1-gip/#comment-725 Tue, 09 Feb 2010 00:35:07 +0000 http://diabeticmediterraneandiet.com/?p=1181#comment-725 Yeah, the problem with so many of these diabetes drugs is that we don’t have good drug-specific data on hard clinical endpoints, such as cardiovascular disease, blindness, kidney impairment, and death.

-Steve

]]> By: isaac http://diabeticmediterraneandiet.com/2010/02/08/glucose-control-by-insulin-amylin-glucagon-glp1-gip/#comment-723 Mon, 08 Feb 2010 20:40:55 +0000 http://diabeticmediterraneandiet.com/?p=1181#comment-723 I’m not impressed with the DPP-IV inhibitors. Unless Merck gets some really impressive data with Januvia and the cardiovascular outcomes trial they’re setting up, a 0.5 to 0.7 absolute drop in A1c seems pretty meager.

I do think the incretin mimetics like Byetta, though, will likely have pleiotropic effects that have beneficial effects on the disease state above and beyond just A1c lowering. Combination therapies may be especially interesting. Time will tell.

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