Comments on: Drug Review: Thiazolidinediones (pioglitazone, rosiglitazone) http://diabeticmediterraneandiet.com/2010/02/05/drug-review-thiazolidinediones-pioglitazone-rosiglitazone/ Conquer Diabetes and Prediabetes With Low-Carb Eating Sat, 19 May 2012 12:43:19 +0000 hourly 1 http://wordpress.com/ By: Steve Parker, M.D. http://diabeticmediterraneandiet.com/2010/02/05/drug-review-thiazolidinediones-pioglitazone-rosiglitazone/#comment-711 Sat, 06 Feb 2010 06:20:13 +0000 http://diabeticmediterraneandiet.com/?p=1113#comment-711 According to UpToDate.com:

Lipid changes overall favor pio over rosi.
With pio, LDL chol tends to hold steady; with rosi, LDL is up 8-16%.
HDL chol up 10% with both.

No one knows with certainty how this affects cardiovascular outcomes, except the CEOs and marketing directors of the two companies that make the drugs.

]]> By: isaac http://diabeticmediterraneandiet.com/2010/02/05/drug-review-thiazolidinediones-pioglitazone-rosiglitazone/#comment-708 Sat, 06 Feb 2010 03:44:21 +0000 http://diabeticmediterraneandiet.com/?p=1113#comment-708 Doesn’t rosi increase absolute LDL levels overall, though? I wonder how much that goes towards explaining the difference between rosi and pio with respect to cardiovascular outcomes.

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