Comments on: Low-Carb Ketogenic Diet for Overweight Diabetic Men: A Pilot Study http://diabeticmediterraneandiet.com/2009/11/22/low-carb-ketogenic-diet-for-overweight-diabetic-men-a-pilot-study/ Conquer Diabetes and Prediabetes With Low-Carb Eating Thu, 29 Jul 2010 22:06:01 +0000 hourly 1 http://wordpress.com/ By: Steve Parker, M.D. http://diabeticmediterraneandiet.com/2009/11/22/low-carb-ketogenic-diet-for-overweight-diabetic-men-a-pilot-study/#comment-694 Steve Parker, M.D. Sat, 30 Jan 2010 17:11:58 +0000 http://diabeticmediterraneandiet.com/?p=881#comment-694 That's a tall order, Beverly! Just tell him, "Dr. Parker says you need to get your BMI down to 30 or less. Doctors orders!" -Steve That’s a tall order, Beverly!

Just tell him, “Dr. Parker says you need to get your BMI down to 30 or less. Doctors orders!”

-Steve

]]> By: Beverly Williams http://diabeticmediterraneandiet.com/2009/11/22/low-carb-ketogenic-diet-for-overweight-diabetic-men-a-pilot-study/#comment-691 Beverly Williams Fri, 29 Jan 2010 23:56:29 +0000 http://diabeticmediterraneandiet.com/?p=881#comment-691 My husband is not diabetic but his BMI is 37. He suffers from COPD and sleep apnea, and while his weight seems to be contributing to his physical discomfort, it is not enough to get him to eat healthy. Any suggestions to change his attitude? My husband is not diabetic but his BMI is 37. He suffers from COPD and sleep apnea, and while his weight seems to be contributing to his physical discomfort, it is not enough to get him to eat healthy. Any suggestions to change his attitude?

]]> By: isaac http://diabeticmediterraneandiet.com/2009/11/22/low-carb-ketogenic-diet-for-overweight-diabetic-men-a-pilot-study/#comment-477 isaac Tue, 24 Nov 2009 02:25:08 +0000 http://diabeticmediterraneandiet.com/?p=881#comment-477 An interesting study in rats looking at a potential causal relationship of uric acid and insulin resistance. http://ajprenal.physiology.org/cgi/content/abstract/00140.2005v1 Of course, any animal experiment carries all sorts of caveats as to the relation to human disease. I'm not sure of the mechanism (potential cotransport, compensatory antioxidant?) but it does seem to correlate in humans. Causality is another thing. I have a hard time believing that allopurinol is going to affect A1c levels. http://rheumatology.oxfordjournals.org/cgi/content/full/47/5/713 http://www.ncbi.nlm.nih.gov/pubmed/19403709?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=11 http://www.ncbi.nlm.nih.gov/pubmed/19375714?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=13 An interesting study in rats looking at a potential causal relationship of uric acid and insulin resistance.

http://ajprenal.physiology.org/cgi/content/abstract/00140.2005v1

Of course, any animal experiment carries all sorts of caveats as to the relation to human disease. I’m not sure of the mechanism (potential cotransport, compensatory antioxidant?) but it does seem to correlate in humans. Causality is another thing. I have a hard time believing that allopurinol is going to affect A1c levels.

http://rheumatology.oxfordjournals.org/cgi/content/full/47/5/713

http://www.ncbi.nlm.nih.gov/pubmed/19403709?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=11

http://www.ncbi.nlm.nih.gov/pubmed/19375714?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=13

]]> By: Steve Parker, M.D. http://diabeticmediterraneandiet.com/2009/11/22/low-carb-ketogenic-diet-for-overweight-diabetic-men-a-pilot-study/#comment-476 Steve Parker, M.D. Mon, 23 Nov 2009 16:40:37 +0000 http://diabeticmediterraneandiet.com/?p=881#comment-476 [For non-Isaacs, note that uric acid is a breakdown product of protein metabolism. Gout is caused by uric acid crystalization inside joints - very painful. Low-carb diets are usually higher than average in protein intake, not uncommonly 28-30% of total energy. Average protein consumption is 15-20% of total energy.] I'm not aware of thiazoladinediones or metformin affecting uric acid levels. I made note of the lowered uric acid level in this study because low carb diets are associated with elevated uric acid and gout attacks, in the literature anyway. I'm not sure of the uric acid-fructose connection. -Steve [For non-Isaacs, note that uric acid is a breakdown product of protein metabolism. Gout is caused by uric acid crystalization inside joints - very painful. Low-carb diets are usually higher than average in protein intake, not uncommonly 28-30% of total energy. Average protein consumption is 15-20% of total energy.]

I’m not aware of thiazoladinediones or metformin affecting uric acid levels. I made note of the lowered uric acid level in this study because low carb diets are associated with elevated uric acid and gout attacks, in the literature anyway.

I’m not sure of the uric acid-fructose connection.

-Steve

]]> By: isaac http://diabeticmediterraneandiet.com/2009/11/22/low-carb-ketogenic-diet-for-overweight-diabetic-men-a-pilot-study/#comment-475 isaac Mon, 23 Nov 2009 15:02:38 +0000 http://diabeticmediterraneandiet.com/?p=881#comment-475 Is this decrease in uric acid due to decreased fructose consumption? Or do things like metformin and TZDs reduce uric acid, too? Is this decrease in uric acid due to decreased fructose consumption? Or do things like metformin and TZDs reduce uric acid, too?

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